WikiMSK:Updates

Latest RCTs

Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS): CONCLUSIONS: This study elucidates how CRPS affects cognitive functioning, important information when tailoring multidisciplinary rehabilitation to CRPS patients. Psychological factors may have a s...; E Kalso. European journal of pain (London, England). 2025-07-08 00:00:00
Cluster-Randomised Controlled Trial of At-Home Virtual Reality for People With Chronic Musculoskeletal Pain on the Waiting List: BACKGROUND: Virtual reality (VR) has been introduced as a novel intervention in chronic musculoskeletal pain (CMP) rehabilitation. However, much remains unknown about the effectiveness of VR for CM...; Monique Tabak. European journal of pain (London, England). 2025-07-05 00:00:00
Attentional Focus but Not Distraction or Expectations Influence Conditioned Pain Modulation in Healthy Adults: CONCLUSIONS: Since attentional focus on the CS reduces CPM efficacy, it is recommended to not rate the CS pain intensity during CS application to prevent a reduction of the inhibitory effect. Furth...; Jessica Van Oosterwijck. European journal of pain (London, England). 2025-06-21 00:00:00
Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled Trial: CONCLUSION: The results indicated that neuromuscular exercise combined with PNE significantly reduced TSP at the index knee, suggesting a reduction in central pain amplification. The clinical impor...; Lars Arendt-Nielsen. European journal of pain (London, England). 2025-06-20 00:00:00
Are self-reported exercise adherence measures associated with pain and function outcomes among participants receiving treatment for Achilles tendinopathy? A secondary analysis of a randomised contr...: CONCLUSION: Although adherence to frequency of exercise is commonly assessed in the literature, it was not associated with clinical outcomes in people with Achilles tendinopathy performing a 12-wee...; Peter Malliaras. Musculoskeletal science & practice. 2025-06-10 00:00:00
Could the Hanging Drop Technique Be an Alternative Method to Loss of Resistance in Cervical Epidural Injections?: CONCLUSIONS: The LOR technique was superior to the HD for cervical ILESIs. More studies with larger sample sizes may provide more precise and detailed information.; Hamit Goksu. Pain physician. 2025-06-04 00:00:00
Safety and Efficacy of Platelet-Rich Plasma versus Genicular Nerve Radiofrequency Ablation in Knee Osteoarthritis: An Open-Label, Prospective, Randomized, Clinical Trial: CONCLUSION: For patients with chronic knee osteoarthritis, intraarticular platelet-rich plasma therapy may offer superior sustained pain relief and a lower disability index compared to conventional...; Annu Navani. Pain physician. 2025-06-04 00:00:00
Effects of combining manual therapies, neck muscle exercises, and therapeutic education pain neuroscience in patients with migraine: a 3-armed randomized clinical trial: CONCLUSION: Although all treatments were effective, MUG was superior in sustaining reductions in headache impact at follow-up, and improving psychosocial, headache and neck-related outcomes.; Débora Bevilaqua-Grossi. Musculoskeletal science & practice. 2025-06-03 00:00:00
Short-Term Effects of Kinesio Taping on Pain and Functionality in Patients With Cervical Spine Surgery: CONCLUSION: Integrating KT into a CR programme during the early postoperative phase of cervical spine surgery may improve clinical outcomes, specifically in pain intensity, PPT, disability levels a...; Zafer O Toktaş. European journal of pain (London, England). 2025-05-29 00:00:00
Minimum clinically important difference of the original and short-form Örebro musculoskeletal pain questionnaire for low back pain: CONCLUSIONS: Both questionnaires were suitable for detecting change over time. To our knowledge, this is the first study to report a MCID estimation for either questionnaire.; Andrew Hahne. Musculoskeletal science & practice. 2025-05-14 00:00:00
Modic Change Edema in Chronic Low Back Pain Treated With Infliximab or Placebo: The BackToBasic Trial: CONCLUSION: Infliximab had no clinically relevant edema reducing effect. MC edema did not modify the effect of infliximab on disability or LBP, nor did the MC-related ADC value.; Ansgar Espeland. Spine. 2025-05-13 00:00:00
Impact of Intermittent Theta Burst Stimulation on Pain Relief and Brain Connectivity in Chronic Low Back Pain: CONCLUSION: iTBS may alleviate pain in CLBP patients by enhancing DLPFC connectivity with the cerebellum and occipital gyrus.; Chuhuai Wang. European journal of pain (London, England). 2025-05-05 00:00:00
HOPE for Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD)-A Pilot Randomised Controlled Trial of Feasibility, Acceptability and Appropriateness: CONCLUSION: The HOPE program seemed feasible, acceptable and appropriate, with preliminary improvements in worst pain intensity and impact of hypermobility. Our findings warrant a fully powered tri...; Cliffton Chan. European journal of pain (London, England). 2025-04-29 00:00:00
Manual therapy and neck-specific exercise are equally effective for treating non-specific neck pain but only when exercise adherence is maximised: A randomised controlled trial: CONCLUSION: A four-week intervention of manual therapy was more effective than exercise, however when exercise adherence was ≥95 %, the interventions were equally effective. Manual therapy may on...; Ion Lascurain-Aguirrebeña. Musculoskeletal science & practice. 2025-04-24 00:00:00
Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318: The transient receptor potential cation channel member A1 (TRPA1) is heavily implicated in nociceptive signaling in both physiological and pathological pain states. However, it has been challenging...; August V Wilke. Pain. 2025-04-21 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. RCTs from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

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Latest Systematic Reviews

Comparative efficacy and acceptability of different intensity levels of extracorporeal shock wave therapy in adults with plantar heel pain: A systematic review and network meta-analysis: CONCLUSION: Compared to the placebo, all intensity levels of ESWT were more favorable in terms of efficacy, but there was no difference in terms of acceptability. In addition, M-ESWT appeared to pr...; Xinwen Cui. PM & R : the journal of injury, function, and rehabilitation. 2025-07-25 00:00:00
Enhancing clinical translation of analgesics for neuropathic pain: a systematic review and meta-analysis on the role of non-evoked pain assessment in preclinical trials: Current therapies for neuropathic pain are often inadequate and several promising preclinical drugs have failed in clinical trials. This may stem from an overreliance on reflex-based outcomes, whic...; Carolina Roza. Pain. 2025-07-24 00:00:00
Analgesic benefits of pharmacological and nonpharmacological sleep interventions for adults with fibromyalgia: a systematic review and meta-analyses: Fibromyalgia is a chronic musculoskeletal pain condition affecting 2% to 8% of the population. Most people with fibromyalgia experience poor sleep, and sleep problems consistently predict pain seve...; Tim Vaughn Salomons. Pain. 2025-07-24 00:00:00
Understanding the untreated course of adults with chronic pain seeking psychological intervention: a systematic review and meta-analysis: The untreated course of chronic pain is not well understood, despite the importance of this information for treatment planning and benchmarking. This study examined symptom change over time and pot...; Blake F Dear. Pain. 2025-07-24 00:00:00
Physiotherapy for endometriosis-associated pelvic pain: A systematic review and meta-analysis: CONCLUSION: Physiotherapy techniques are effective in reducing pain in women with endometriosis, especially when applied locally.; Nándor Ács. Pain medicine (Malden, Mass.). 2025-07-24 00:00:00
The characterization of frailty in spine surgery: a systematic review of frailty indices: CONCLUSION: While mFI-5 and mFI-11 are commonly used, their comorbidity-based approach limits frailty assessment. Future research should prioritize multidimensional indices like the Fried Frailty I...; Mitchell S Fourman. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2025-07-21 00:00:00
Associations Between Sum Scores or Combinations of MRI Findings in the Lumbar Spine and Low Back Pain-Related Outcomes: A Systematic Review: CONCLUSION: Most studies reported stronger associations between increasing sum scores of MRI findings and LBP. We recommend focusing on cumulative MRI findings when investigating the relationship w...; Rikke Krüger Jensen. European journal of pain (London, England). 2025-07-18 00:00:00
Evaluating Predictive Performance and Generalizability of Traditional and Artificial Intelligence Models in Predicting Surgical Site Infections Post-Spinal Surgery: A Systematic Review: CONCLUSIONS: This systematic review, the first of its kind, observed that studies utilizing the ML models reported a potential for excellent classification accuracy in predicting SSI following spin...; Elie F Berbari. The spine journal : official journal of the North American Spine Society. 2025-07-16 00:00:00
Answer to the letter to the editor of T. Tu concerning "Machine learning-based models for outcome prediction in skull base and spinal chordomas: a systematic review and meta-analysis" by B. Hajikar...: No abstract; Mohammad Amin Habibi. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2025-07-15 00:00:00
Risk factors for adjacent vertebral fracture after kyphoplasty or percutaneous vertebroplasty in osteoporotic vertebral systematic review and meta-analysis compression fractures: CONCLUSION: There are many risk factors for adjacent vertebral re-fracture after vertebroplasty for osteoporotic vertebral compression fractures. Medical staff should make comprehensive assessment,...; Zhiwei Li. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2025-07-14 00:00:00
Risk factors for new vertebral fracture after percutaneous vertebroplasty or kyphoplasty for osteoporotic vertebral compression fractures (OVCFs): an updated systematic review and meta-analysis: CONCLUSION: Significant risk factors for NVCF after PVP and PKP include older age, female sex, higher number of treated vertebrae, and cement leakage. The findings highlight the importance of caref...; Ji-Ying Chen. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2025-07-14 00:00:00
The Role of the Iron-Chelating Agent Deferoxamine in Spinal Cord Injury: A Systematic Review and Meta-Analysis of Preclinical Studies: CONCLUSION: We demonstrated that deferoxamine improves hindlimb motor function in animal models of SCI. Potential knowledge gaps exist, necessitating future animal studies across a more diverse ran...; Michael G Fehlings. The spine journal : official journal of the North American Spine Society. 2025-07-13 00:00:00
Does Cognition Status Affect Spinal Surgery Outcomes: A Systematic Review and Meta-Analysis: CONCLUSION: This study suggests that preoperative CI is associated with worse postoperative health outcomes and inferior facility-based measures in patients undergoing spine surgery. These findings...; Owoicho Adogwa. The spine journal : official journal of the North American Spine Society. 2025-07-11 00:00:00
A novel dura splitting technique for surgical resection of anterior spinal meningioma: a case series and systematic review of the literature: No abstract; Asem Almomani. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2025-07-11 00:00:00
Agreement between high-quality clinical practice guidelines in their treatment recommendations for low back pain: A systematic review: CONCLUSION: More research is needed to understand reasons for these disagreements as well as the variation across clinical practice guidelines in electing to make a recommendation.; Rachelle Buchbinder. The spine journal : official journal of the North American Spine Society. 2025-07-10 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. Reviews from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

Pubmed Link