EBQ:Twin Spine Study: Difference between revisions
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==Outcomes/Results== | ==Outcomes/Results== | ||
===Primary Outcomes=== | ===Primary Outcomes=== | ||
[[File:determinants of disc degeneration.PNG|400px|The variability (adj. R2) in qualitative disc degeneration summary scores explained by physical loading, age, and familial aggregation (proxy of heredity) demonstrated that significantly more variability remained unexplained in the L4โS1 disc levels.]] | |||
===Secondary Outcomes=== | ===Secondary Outcomes=== | ||
====Adverse events==== | ====Adverse events==== |
Revision as of 07:30, 24 June 2020
PubMed PDF
Clinical Question
What is the contribution of genetics to disc degeneration?
Conclusion
There is a substantial influence of heredity on lumbar disc degeneration. There is little effect on disc degeneration from occupational and leisure-time physical loading, and increased loading may have a small benefit. There is only a small effect from smoking. Body weight and muscle strength have modest effects on disc degeneration. Some candidate genes were identified.
Design
The Twin Spine Study, which started in 1991, is a multidisciplinary, multinational research project with collaborators primarily in Canada, Finland, and the United States. They investigated occupational exposures, driving and whole-body vibration exposure, smoking exposure, anthropomorphic factors, heritability, and the identification of genotypes associated with disc degeneration.