WikiMSK:Updates

Latest RCTs

Does Adding Electroanalgesic Modalities to a Multimodal Therapeutic Program Improve Clinical Outcomes in Individuals With Chronic Nonspecific Neck Pain? A Randomised Controlled Trial: CONCLUSIONS: The addition of IFC and/or TENS to an MTIP did not enhance clinical outcomes in individuals with CNSNP.; Cid André Fidelis de Paula Gomes. European journal of pain (London, England). 2025-09-05 00:00:00
Prevalence of Chronic Overlapping Pain Conditions in Participants With Chronic Low Back Pain Enrolled in a Pragmatic Trial of Mindfulness-Based Stress Reduction: CONCLUSION: We found strong differences when comparing people with cLBP alone to those with cLBP and COPCs. People with COPCs reported more pain symptoms, higher levels of anxiety, depression, fati...; Natalia E Morone. European journal of pain (London, England). 2025-09-02 00:00:00
A within-subject, double-blind, placebo-controlled randomized evaluation of the combined effects of cannabidiol and hydromorphone in a human laboratory pain model: Preclinical and epidemiological evidence supports that cannabinoids may have opioid-sparing properties and could be one strategy to decrease opioid use and associated harms like overdose and extram...; Kelly E Dunn. Pain. 2025-08-21 00:00:00
Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial: Our group has shown that translocator protein (TSPO) levels, a putative marker of neuroinflammation, are increased in the brain and spinal cord of patients with chronic low back pain (cLBP). Whethe...; Marco L Loggia. Pain. 2025-08-21 00:00:00
Moderators of digital cognitive-behavioral therapy for youth with sickle cell disease pain: secondary analysis of a randomized controlled trial: Pain is the hallmark symptom of sickle cell disease (SCD). By adolescence, 20% of youth with SCD develop chronic SCD pain. Our randomized controlled trial found significant reductions in pain in yo...; Jennifer N Stinson. Pain. 2025-08-21 00:00:00
Effects of Dexamethasone Administration in Sphenopalatine Ganglion Block for Allergic Rhinitis: A Prospective, Randomized, Single-blind Controlled Trial: CONCLUSIONS: Ultrasound-guided SPGB is a safe and effective treatment for AR, improving symptoms, quality of life, and nasal airflow. The addition of corticosteroids may enhance short-term efficacy.; Lijuan Lu. Pain physician. 2025-08-07 00:00:00
Atelocollagen vs. Prolotherapy in Partial-Thickness Supraspinatus Tears: A Prospective Randomized Controlled Trial with MRI-Confirmed Outcomes: CONCLUSIONS: In patients with PTSTs, atelocollagen injections provided more efficient pain relief and demonstrated greater structural improvements than did prolotherapy, as confirmed by MRI. While ...; Pyung Bok Lee. Pain physician. 2025-08-07 00:00:00
Self-Chosen Music as a Contributor to Music-Induced Analgesia Across Diverse Socio-Cultural Backgrounds: A Crossover Randomised Controlled Trial: CONCLUSIONS: Listening to self-chosen music was effective in MIA, irrespective of socio-cultural background or type of music. In contrast, researcher-chosen (classical) music was most effective in ...; Markus Klimek. European journal of pain (London, England). 2025-08-07 00:00:00
Effectiveness of Equimolar Mixture of Oxygen and Nitrous Oxide Combined With Audiovisual in Young Children: A Randomised Controlled Trial: CONCLUSION: The combination of audiovisuals with EMONO may be effective in increasing cooperation and reducing pain in children 2-5 years during PVC placement.; Valeria Carla Edefonti. European journal of pain (London, England). 2025-08-05 00:00:00
Effectiveness of an active behavioural physiotherapy intervention (ABPI) for chronic non-specific neck pain: an internal pilot cluster-randomised double-blind clinical trial: CONCLUSION: These promising findings from an internal pilot study support continued data collection to conduct the definitive phase III trial (n = 120) to evaluate the effectiveness of the ABPI for...; Alison Rushton. Musculoskeletal science & practice. 2025-08-03 00:00:00
Optimizing acute pain relief in severe knee Osteoarthritis: The influence of resistance exercise volume and psychosocial factors: CONCLUSIONS: Greater resistance exercise volume appears to be associated with an initial increase in pain perception followed by a delayed hypoalgesic response in patients with severe knee OA. Thes...; Joaquín Calatayud. Musculoskeletal science & practice. 2025-08-03 00:00:00
Alcohol-Induced Disinhibition of Facial Responses to Pain: BACKGROUND: Alcohol in sub-toxic dosages has appeared to slightly reduce experimental pain in psychophysical paradigms. However, this effect may also reflect impaired scaling performance in subject...; Miriam Kunz. European journal of pain (London, England). 2025-08-02 00:00:00
It Is Time to Feel Better: How Temporal Information of Placebo Analgesia Affects Our Brain: CONCLUSION: This study proposes that the cortical network related to the placebo effect may be active and modulated by temporal information of cream effectiveness, as well as their behavioural resp...; Carlino Elisa. European journal of pain (London, England). 2025-08-01 00:00:00
Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS): CONCLUSIONS: This study elucidates how CRPS affects cognitive functioning, important information when tailoring multidisciplinary rehabilitation to CRPS patients. Psychological factors may have a s...; E Kalso. European journal of pain (London, England). 2025-07-08 00:00:00
The EMU manipulation study: A randomized trial investigating the efficacy of matched or unmatched cervical/thoracic manipulations on neck pain: CONCLUSIONS: Both matched and unmatched manipulations significantly reduced pain with movement, with no differences based on CTDT results. In the context of a rigorously blinded trial, cervical and...; Paul Artzer. Musculoskeletal science & practice. 2025-07-06 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. RCTs from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

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Latest Systematic Reviews

Enhancing Physical Activity in Health-Impaired Individuals Through Telecoaching: A Systematic Review of Evidence and Practical Applications: CONCLUSION: TC is a safe, effective, and injury-free modality for secondary prevention. Future studies should identify optimal duration (in weeks), frequency (sessions per week), and intensity of T...; Giuseppe Battaglia. American journal of physical medicine & rehabilitation. 2025-09-04 00:00:00
How is wakeful rest operationalized and measured in daily life among adults with and without long-term conditions? A systematic scoping review: A systematic scoping review was conducted to examine how rest is operationalized and measured in daily life among adults with and without long-term conditions. Searches were performed in PubMed, Cu...; Ulric Sena Abonie. PM & R : the journal of injury, function, and rehabilitation. 2025-09-04 00:00:00
Cost-effectiveness of Surgery for Spinal Metastasis: A Systematic Review: CONCLUSIONS: We found CT consisting of surgery and RT to be cost effective in 6 out of 7 (85.7%) studies. Cost effectiveness might be even more pronounced in certain patient subgroups, such as pati...; Atman M Desai. Spine. 2025-09-04 00:00:00
Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies: CONCLUSION: This study revealed that the prevalence of associated NAAs is greater among IS patients with atypical laterality curves, especially in patients with left dorsal curves and/or right lumb...; Rafael Lomas-Vega. Spine. 2025-09-04 00:00:00
Task-specific vs general measures of pain-related fear relative associations with spinal motor behaviour: a systematic review and meta-analysis: Musculoskeletal pain, particularly low back and neck pain, is associated with maladaptive changes in spinal motor behaviour (SMB). Psychological factors such as pain-related fear play a role in dri...; Arnaud F Dupeyron. Pain. 2025-09-02 00:00:00
Healthcare Practitioner and Other Professionals' Perspectives on Gabapentinoid Misuse and Dependence: A Systematic Review of Qualitative Studies: CONCLUSIONS: Gabapentinoid misuse is shaped by clinical, social and structural factors. Tackling these challenges requires systemic responses that go beyond individual prescribers. Lessons from opi...; Bridin Murnion. European journal of pain (London, England). 2025-09-02 00:00:00
Comparative Effectiveness of Exercise Modalities for Fibromyalgia: A Systematic Review and Bayesian Network Meta-Analysis: CONCLUSION: Aerobic + flexibility training and water-based exercises may be effective strategies for pain management in patients with FM. However, given the substantial heterogeneity, high risk of ...; Xiuqiang Wang. European journal of pain (London, England). 2025-09-01 00:00:00
Anterior vs posterior approaches in the management of multilevel degenerative cervical myelopathy: A systematic review and meta-analysis: CONCLUSIONS: Both surgical approaches yield comparable long-term outcomes, with anterior surgery demonstrating statistically significant early functional advantages, shorter LOS, and lower odds of ...; Nisaharan Srikandarajah. The spine journal : official journal of the North American Spine Society. 2025-08-31 00:00:00
Corrections to "Aerobic Exercise Prescription for Pain Reduction in Fibromyalgia: A Systematic Review and Meta-Analysis": No abstract; . European journal of pain (London, England). 2025-08-28 00:00:00
Accuracy and Efficacy of Ultrasound Guided Glenohumeral Joint Injections: A Systematic Review: CONCLUSION: Ultrasound-guided glenohumeral joint injections are more accurate than landmark guided injections and have similar accuracy rates compared to other imaging modalities. Ultrasound-guided...; Nitin B Jain. American journal of physical medicine & rehabilitation. 2025-08-26 00:00:00
Effectiveness of Genicular Nerve Radiofrequency Ablation in Osteoarthritis and Post-surgical Knee Pain: Systematic Review: CONCLUSIONS: GnRFA is effective in reducing knee pain in the majority of patients with osteoarthritis when large lesion techniques are used with moderate-certainty evidence, according to GRADE. Alt...; Reza Ehsanian. Pain medicine (Malden, Mass.). 2025-08-26 00:00:00
Effectiveness of Movement Representation Strategies in Knee Pain: A Systematic Review and Meta-Analyses on Knee Pain and Function: INTRODUCTION: A highly prevalent condition, knee pain often results in significant functional limitations and a reduced quality of life. Due to its multifactorial causes and diverse pathologies, nu...; Marie Carmen Valenza. European journal of pain (London, England). 2025-08-25 00:00:00
Evidence-Based Framework for Identifying Opioid Use Disorder in Administrative Data: A Systematic Review and Methodological Development Study: CONCLUSIONS: An evidence-based framework incorporating diagnosis codes, specific temporal requirements, validated indirect indicators, and treatment evidence provides theoretical foundation for sta...; Meredith C B Adams. Pain medicine (Malden, Mass.). 2025-08-25 00:00:00
Role of stretching interventions in enhancing the shoulder range of motion in overhead athletes with glenohumeral internal rotation deficit: A systematic review and meta-analysis: CONCLUSION: SS or combination of SS and CS interventions significantly enhanced the ROM of IR compared to the control group in overhead athletes diagnosed with GIRD. Furthermore, the review confirm...; Omar A Selim. PM & R : the journal of injury, function, and rehabilitation. 2025-08-22 00:00:00
A systematic review and meta-analysis of pharmacological methods to manipulate experimentally induced secondary hypersensitivity: Understanding the physiology of specific clinical features of persistent pain, such as secondary hypersensitivity, is crucial for developing effective treatments. This systematic review and meta-an...; Victoria J Madden. Pain. 2025-08-21 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. Reviews from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

Pubmed Link