WikiMSK:Updates

Latest RCTs

Effects of Training Modalities and Additional Pain Education on Exercise-Induced Hypoalgesia in People With Osteoarthritis of the Knee: A Randomised Controlled Feasibility Trial: CONCLUSION: Progression to a larger study is warranted. RTL, but also AET and RTU may induce EIH in people with knee OA. Pain education might have a useful supporting function, but its effect would...; Christian Thiel. European journal of pain (London, England). 2025-10-03 00:00:00
Role of Latissimus Dorsi-Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients With Chronic Low Back Pain: A Randomised Clinical Trial: CONCLUSION: The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF...; Sema Nur Aslan. European journal of pain (London, England). 2025-10-02 00:00:00
A Prospective, Randomized, Controlled Clinical Trial of High-Frequency Electromagnetic Coupling Powered Permanent Peripheral Nerve Stimulator for the Treatment of Chronic Craniofacial Pain: CONCLUSION: This RCT operated under an IDE requiring regulatory FDA oversight. This study provides Level 1 evidence for PNS therapy. The positive outcomes of this study support an expanded PNS indi...; Niek E Vanquathem. Pain physician. 2025-09-23 00:00:00
Individual-Level Effects of a Digital Behavioural Treatment for Chronic Pain: Proof-of-Concept of a Single-Case Experimental Design Study: CONCLUSION: The digital behavioural treatment showed promise in addressing diverse pain profiles and associated functioning. The variability in responses highlights the benefit of using SCED to exp...; Rikard K Wicksell. European journal of pain (London, England). 2025-09-18 00:00:00
Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial: CONCLUSIONS: COPCs were common among a sample of veterans in a pragmatic clinical trial. Several baseline differences emerged indicating veterans with COPCs experience greater mental health concern...; Diana J Burgess. European journal of pain (London, England). 2025-09-15 00:00:00
Does Adding Electroanalgesic Modalities to a Multimodal Therapeutic Program Improve Clinical Outcomes in Individuals With Chronic Nonspecific Neck Pain? A Randomised Controlled Trial: CONCLUSIONS: The addition of IFC and/or TENS to an MTIP did not enhance clinical outcomes in individuals with CNSNP.; Cid André Fidelis de Paula Gomes. European journal of pain (London, England). 2025-09-05 00:00:00
Prevalence of Chronic Overlapping Pain Conditions in Participants With Chronic Low Back Pain Enrolled in a Pragmatic Trial of Mindfulness-Based Stress Reduction: CONCLUSION: We found strong differences when comparing people with cLBP alone to those with cLBP and COPCs. People with COPCs reported more pain symptoms, higher levels of anxiety, depression, fati...; Natalia E Morone. European journal of pain (London, England). 2025-09-02 00:00:00
The effects of companionship from strangers and companions on pain thresholds in immersive virtual reality: A randomized controlled trial: CONCLUSIONS: These findings suggest that social interaction, especially in VR, can enhance pain thresholds, with a preference for interacting with companions and demonstrate the potential for socia...; Andrea Stevenson Won. Pain medicine (Malden, Mass.). 2025-09-01 00:00:00
A within-subject, double-blind, placebo-controlled randomized evaluation of the combined effects of cannabidiol and hydromorphone in a human laboratory pain model: Preclinical and epidemiological evidence supports that cannabinoids may have opioid-sparing properties and could be one strategy to decrease opioid use and associated harms like overdose and extram...; Kelly E Dunn. Pain. 2025-08-21 00:00:00
Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial: Our group has shown that translocator protein (TSPO) levels, a putative marker of neuroinflammation, are increased in the brain and spinal cord of patients with chronic low back pain (cLBP). Whethe...; Marco L Loggia. Pain. 2025-08-21 00:00:00
Moderators of digital cognitive-behavioral therapy for youth with sickle cell disease pain: secondary analysis of a randomized controlled trial: Pain is the hallmark symptom of sickle cell disease (SCD). By adolescence, 20% of youth with SCD develop chronic SCD pain. Our randomized controlled trial found significant reductions in pain in yo...; Jennifer N Stinson. Pain. 2025-08-21 00:00:00
Effects of Dexamethasone Administration in Sphenopalatine Ganglion Block for Allergic Rhinitis: A Prospective, Randomized, Single-blind Controlled Trial: CONCLUSIONS: Ultrasound-guided SPGB is a safe and effective treatment for AR, improving symptoms, quality of life, and nasal airflow. The addition of corticosteroids may enhance short-term efficacy.; Lijuan Lu. Pain physician. 2025-08-07 00:00:00
Atelocollagen vs. Prolotherapy in Partial-Thickness Supraspinatus Tears: A Prospective Randomized Controlled Trial with MRI-Confirmed Outcomes: CONCLUSIONS: In patients with PTSTs, atelocollagen injections provided more efficient pain relief and demonstrated greater structural improvements than did prolotherapy, as confirmed by MRI. While ...; Pyung Bok Lee. Pain physician. 2025-08-07 00:00:00
Self-Chosen Music as a Contributor to Music-Induced Analgesia Across Diverse Socio-Cultural Backgrounds: A Crossover Randomised Controlled Trial: CONCLUSIONS: Listening to self-chosen music was effective in MIA, irrespective of socio-cultural background or type of music. In contrast, researcher-chosen (classical) music was most effective in ...; Markus Klimek. European journal of pain (London, England). 2025-08-07 00:00:00
Effectiveness of Equimolar Mixture of Oxygen and Nitrous Oxide Combined With Audiovisual in Young Children: A Randomised Controlled Trial: CONCLUSION: The combination of audiovisuals with EMONO may be effective in increasing cooperation and reducing pain in children 2-5 years during PVC placement.; Valeria Carla Edefonti. European journal of pain (London, England). 2025-08-05 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. RCTs from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

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Latest Systematic Reviews

Worldwide prevalence of dysmenorrhea: a systematic review and meta-analysis across 70 countries: Dysmenorrhea is menstrual pain of uterine origin that can be classified as primary (PD) or secondary (SD). The worldwide prevalence of dysmenorrhea has been estimated in previous systematic reviews...; Mariana Arias Avila. Pain. 2025-10-01 00:00:00
Are psychological factors associated with patient-reported pain and function in individuals with hip joint-related pain? A systematic review: CONCLUSIONS: There is consistent, low- to moderate-grade evidence supporting an association between psychological factors and pain and function in patients with hip joint-related pain at baseline a...; Ana-Maria Vranceanu. PM & R : the journal of injury, function, and rehabilitation. 2025-09-29 00:00:00
Effectiveness of Peripheral Nerve Stimulation in Managing Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials: CONCLUSION: The evidence supports a fair (Level III) level of evidence with moderate certainty and recommendation strength, based on qualitative and quantitative analyses and GRADE assessment.; Joshua A Hirsch. Pain physician. 2025-09-23 00:00:00
Variability of MCID and PASS Thresholds in Anterior Cervical Discectomy and Fusion Literature: A Systematic Review: CONCLUSION: There is a high degree of variability among MCID thresholds in the ACDF literature, especially for NDI, VAS-arm, SF-12 PCS, SF-12 MCS, and PROMIS-PF. Interestingly, threshold values may...; Sheeraz A Qureshi. Spine. 2025-09-23 00:00:00
Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis: Pain is a major complication of sickle cell disease (SCD), and persons with SCD experience acute vaso-occlusive pain episodes (VOEs). Many adults with SCD also develop chronic pain (CP). We conduct...; Nitya Bakshi. Pain. 2025-09-22 00:00:00
Platelet-rich plasma outcomes in knee osteoarthritis are associated with the amount of total deliverable platelets: A systematic review and meta-analysis: CONCLUSIONS: When compared to HA, PRP with platelet counts between 1 and 10 billion total deliverable platelets may result in a larger decrease in pain symptoms when compared to platelet counts gre...; Prathap Jayaram. PM & R : the journal of injury, function, and rehabilitation. 2025-09-22 00:00:00
Mirogabalin for Treatment of Neuropathic Pain and Associated Sleep Interference: An Updated Meta-Analysis: CONCLUSION: In this meta-analysis of RCTs evaluating patients with central and peripheral NeP, mirogabalin significantly improved pain and decreased sleep interference by pain, as compared with pla...; Julyana Medeiros Dantas. European journal of pain (London, England). 2025-09-19 00:00:00
Response to letter to the Editor regarding "Common interventional procedures for chronic non-cancer spine pain: a systematic review and network meta-analysis of randomised trials.": No abstract; Joshua D Rittenberg. The spine journal : official journal of the North American Spine Society. 2025-09-17 00:00:00
Exercise-based rehabilitation for ACL injuries: a systematic review and meta-analysis: CONCLUSION: We found very uncertain benefit of exercise over no treatment, but no exercise was likely more beneficial than another. Compared to exercise, surgery shows no benefit on pain, but a sma...; Peter Stubbs. Musculoskeletal science & practice. 2025-09-17 00:00:00
Enhancing Physical Activity in Health-Impaired Individuals Through Telecoaching: A Systematic Review of Evidence and Practical Applications: CONCLUSION: TC is a safe, effective, and injury-free modality for secondary prevention. Future studies should identify optimal duration (in weeks), frequency (sessions per week), and intensity of T...; Giuseppe Battaglia. American journal of physical medicine & rehabilitation. 2025-09-04 00:00:00
How is wakeful rest operationalized and measured in daily life among adults with and without long-term conditions? A systematic scoping review: A systematic scoping review was conducted to examine how rest is operationalized and measured in daily life among adults with and without long-term conditions. Searches were performed in PubMed, Cu...; Ulric Sena Abonie. PM & R : the journal of injury, function, and rehabilitation. 2025-09-04 00:00:00
Cost-effectiveness of Surgery for Spinal Metastasis: A Systematic Review: CONCLUSIONS: We found CT consisting of surgery and RT to be cost effective in 6 out of 7 (85.7%) studies. Cost effectiveness might be even more pronounced in certain patient subgroups, such as pati...; Atman M Desai. Spine. 2025-09-04 00:00:00
Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies: CONCLUSION: This study revealed that the prevalence of associated NAAs is greater among IS patients with atypical laterality curves, especially in patients with left dorsal curves and/or right lumb...; Rafael Lomas-Vega. Spine. 2025-09-04 00:00:00
Task-specific vs general measures of pain-related fear relative associations with spinal motor behaviour: a systematic review and meta-analysis: Musculoskeletal pain, particularly low back and neck pain, is associated with maladaptive changes in spinal motor behaviour (SMB). Psychological factors such as pain-related fear play a role in dri...; Arnaud F Dupeyron. Pain. 2025-09-02 00:00:00
Healthcare Practitioner and Other Professionals' Perspectives on Gabapentinoid Misuse and Dependence: A Systematic Review of Qualitative Studies: CONCLUSIONS: Gabapentinoid misuse is shaped by clinical, social and structural factors. Tackling these challenges requires systemic responses that go beyond individual prescribers. Lessons from opi...; Bridin Murnion. European journal of pain (London, England). 2025-09-02 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. Reviews from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

Pubmed Link