WikiMSK:Updates

Latest RCTs

Effects of Dexamethasone Administration in Sphenopalatine Ganglion Block for Allergic Rhinitis: A Prospective, Randomized, Single-blind Controlled Trial: CONCLUSIONS: Ultrasound-guided SPGB is a safe and effective treatment for AR, improving symptoms, quality of life, and nasal airflow. The addition of corticosteroids may enhance short-term efficacy.; Lijuan Lu. Pain physician. 2025-08-07 00:00:00
Atelocollagen vs. Prolotherapy in Partial-Thickness Supraspinatus Tears: A Prospective Randomized Controlled Trial with MRI-Confirmed Outcomes: CONCLUSIONS: In patients with PTSTs, atelocollagen injections provided more efficient pain relief and demonstrated greater structural improvements than did prolotherapy, as confirmed by MRI. While ...; Pyung Bok Lee. Pain physician. 2025-08-07 00:00:00
Self-Chosen Music as a Contributor to Music-Induced Analgesia Across Diverse Socio-Cultural Backgrounds: A Crossover Randomised Controlled Trial: CONCLUSIONS: Listening to self-chosen music was effective in MIA, irrespective of socio-cultural background or type of music. In contrast, researcher-chosen (classical) music was most effective in ...; Markus Klimek. European journal of pain (London, England). 2025-08-07 00:00:00
Effectiveness of Equimolar Mixture of Oxygen and Nitrous Oxide Combined With Audiovisual in Young Children: A Randomised Controlled Trial: CONCLUSION: The combination of audiovisuals with EMONO may be effective in increasing cooperation and reducing pain in children 2-5 years during PVC placement.; Valeria Carla Edefonti. European journal of pain (London, England). 2025-08-05 00:00:00
Alcohol-Induced Disinhibition of Facial Responses to Pain: BACKGROUND: Alcohol in sub-toxic dosages has appeared to slightly reduce experimental pain in psychophysical paradigms. However, this effect may also reflect impaired scaling performance in subject...; Miriam Kunz. European journal of pain (London, England). 2025-08-02 00:00:00
It Is Time to Feel Better: How Temporal Information of Placebo Analgesia Affects Our Brain: CONCLUSION: This study proposes that the cortical network related to the placebo effect may be active and modulated by temporal information of cream effectiveness, as well as their behavioural resp...; Carlino Elisa. European journal of pain (London, England). 2025-08-01 00:00:00
Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS): CONCLUSIONS: This study elucidates how CRPS affects cognitive functioning, important information when tailoring multidisciplinary rehabilitation to CRPS patients. Psychological factors may have a s...; E Kalso. European journal of pain (London, England). 2025-07-08 00:00:00
Cluster-Randomised Controlled Trial of At-Home Virtual Reality for People With Chronic Musculoskeletal Pain on the Waiting List: BACKGROUND: Virtual reality (VR) has been introduced as a novel intervention in chronic musculoskeletal pain (CMP) rehabilitation. However, much remains unknown about the effectiveness of VR for CM...; Monique Tabak. European journal of pain (London, England). 2025-07-05 00:00:00
Attentional Focus but Not Distraction or Expectations Influence Conditioned Pain Modulation in Healthy Adults: CONCLUSIONS: Since attentional focus on the CS reduces CPM efficacy, it is recommended to not rate the CS pain intensity during CS application to prevent a reduction of the inhibitory effect. Furth...; Jessica Van Oosterwijck. European journal of pain (London, England). 2025-06-21 00:00:00
Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled Trial: CONCLUSION: The results indicated that neuromuscular exercise combined with PNE significantly reduced TSP at the index knee, suggesting a reduction in central pain amplification. The clinical impor...; Lars Arendt-Nielsen. European journal of pain (London, England). 2025-06-20 00:00:00
Are self-reported exercise adherence measures associated with pain and function outcomes among participants receiving treatment for Achilles tendinopathy? A secondary analysis of a randomised contr...: CONCLUSION: Although adherence to frequency of exercise is commonly assessed in the literature, it was not associated with clinical outcomes in people with Achilles tendinopathy performing a 12-wee...; Peter Malliaras. Musculoskeletal science & practice. 2025-06-10 00:00:00
Could the Hanging Drop Technique Be an Alternative Method to Loss of Resistance in Cervical Epidural Injections?: CONCLUSIONS: The LOR technique was superior to the HD for cervical ILESIs. More studies with larger sample sizes may provide more precise and detailed information.; Hamit Goksu. Pain physician. 2025-06-04 00:00:00
Safety and Efficacy of Platelet-Rich Plasma versus Genicular Nerve Radiofrequency Ablation in Knee Osteoarthritis: An Open-Label, Prospective, Randomized, Clinical Trial: CONCLUSION: For patients with chronic knee osteoarthritis, intraarticular platelet-rich plasma therapy may offer superior sustained pain relief and a lower disability index compared to conventional...; Annu Navani. Pain physician. 2025-06-04 00:00:00
Effects of combining manual therapies, neck muscle exercises, and therapeutic education pain neuroscience in patients with migraine: a 3-armed randomized clinical trial: CONCLUSION: Although all treatments were effective, MUG was superior in sustaining reductions in headache impact at follow-up, and improving psychosocial, headache and neck-related outcomes.; Débora Bevilaqua-Grossi. Musculoskeletal science & practice. 2025-06-03 00:00:00
Short-Term Effects of Kinesio Taping on Pain and Functionality in Patients With Cervical Spine Surgery: CONCLUSION: Integrating KT into a CR programme during the early postoperative phase of cervical spine surgery may improve clinical outcomes, specifically in pain intensity, PPT, disability levels a...; Zafer O Toktaş. European journal of pain (London, England). 2025-05-29 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. RCTs from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

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Latest Systematic Reviews

Reliability of Temporal Summation of Pain in Healthy and Clinical Populations: A Systematic Review and Meta-Analysis: CONCLUSION: TSP demonstrates moderate reliability, influenced by stimulus parameters and population. Small-area mechanical stimuli (e.g., pinprick), tested at 1 Hz using absolute change scores, yie...; Rutger Marinus Johannes de Zoete. European journal of pain (London, England). 2025-08-08 00:00:00
Preemptive Acetaminophen for Postoperative Analgesia in Children Undergoing Surgery: A Systematic Review and Meta-Analysis: CONCLUSION: Preemptive acetaminophen in pediatric patients could effectively alleviate postoperative pain and decrease the need for additional rescue analgesic interventions.; Wei-Bing Tang. Pain physician. 2025-08-07 00:00:00
A Systematic Review And Meta-Analysis Of Randomized Trials Of Therapeutic Intraarticular Facet Joint Injections In Chronic Axial Spinal Pain: CONCLUSION: Based on qualitative analysis and GRADE assessment, intraarticular facet joint injections are supported by Level IV evidence, with limited quality, low certainty, and a low strength of ...; Joshua A Hirsch. Pain physician. 2025-08-07 00:00:00
Generation and validation of a Hounsfield unit (HU) threshold for predicting mechanical and junctional complications following thoracolumbar or lumbar fusion: a systematic review and meta-analysis: CONCLUSION: In patients undergoing thoracolumbar or lumbar fusions, preoperative Hounsfield unit values under 118 were associated with a 2.8-fold higher risk of postoperative mechanical and junctio...; Alan Daniels. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2025-08-04 00:00:00
Exercise Therapy Versus Manual Therapy for the Management of Pain Intensity, Disability, and Physical Function in People With Chronic Low Back Pain: A Systematic Review With Meta-Analysis and Meta-...: CONCLUSIONS: ET had a small beneficial effect on long-term disability in people with CLBP. Nevertheless, evidence does not provide conclusive differences between both the treatments overall, influe...; Álvaro-José Rodríguez-Domínguez. European journal of pain (London, England). 2025-08-01 00:00:00
Four MBE Therapies to Improve Pain Scores, Physical Functioning, and Quality of Life in Patients With Chronic Nonspecific Low Back Pain: Network Meta-Analysis of Randomised Controlled Trials: CONCLUSION: QG is the most effective for pain relief and improving physical function, while TC best enhances QoL. Different MBEs have distinct effects on functional outcomes, suggesting that interv...; Rui Huang. European journal of pain (London, England). 2025-07-31 00:00:00
Accuracy and Efficacy of Intra-Articular Knee Injections/Aspirations Under Ultrasound versus Landmark Guidance: A Systematic Review: CONCLUSIONS: This systematic review provides data to support that US-guided intra-articular knee injections/aspirations are more accurate and efficacious than LM-guided intra-articular knee injecti...; Nitin B Jain. American journal of physical medicine & rehabilitation. 2025-07-29 00:00:00
Measurement instruments of pain-related avoidance in chronic pain: a systematic review of psychometric properties: Avoiding harmful events is adaptive in the short term but eventually may compromise functioning in daily life. Therefore, assessing pain-related avoidance is important in both pain research and tre...; Johan W S Vlaeyen. Pain. 2025-07-29 00:00:00
Are There Racial and Ethnic Disparities in Sleep Problems Among People with Chronic Pain? Systematic Review and Meta-Analysis: CONCLUSION: We found that the prevalence of sleep problems does not differ substantially by race as a comorbidity of chronic pain. However, certain groups, such as Hispanics, remain understudied. M...; Kosaku Aoyagi. Pain medicine (Malden, Mass.). 2025-07-28 00:00:00
Are GLP-1 Receptor Agonists Safe in Spine Surgery: A Systematic Review: CONCLUSION: This review highlights the current understanding of GLP-1 RA's impact on spine surgery. Retrospective studies demonstrate mixed and contradictory results on the impact of GLP-1 RAs on m...; Philip K Louie. Spine. 2025-07-28 00:00:00
Comparative efficacy and acceptability of different intensity levels of extracorporeal shock wave therapy in adults with plantar heel pain: A systematic review and network meta-analysis: CONCLUSION: Compared to the placebo, all intensity levels of ESWT were more favorable in terms of efficacy, but there was no difference in terms of acceptability. In addition, M-ESWT appeared to pr...; Xinwen Cui. PM & R : the journal of injury, function, and rehabilitation. 2025-07-25 00:00:00
Enhancing clinical translation of analgesics for neuropathic pain: a systematic review and meta-analysis on the role of non-evoked pain assessment in preclinical trials: Current therapies for neuropathic pain are often inadequate and several promising preclinical drugs have failed in clinical trials. This may stem from an overreliance on reflex-based outcomes, whic...; Carolina Roza. Pain. 2025-07-24 00:00:00
Analgesic benefits of pharmacological and nonpharmacological sleep interventions for adults with fibromyalgia: a systematic review and meta-analyses: Fibromyalgia is a chronic musculoskeletal pain condition affecting 2% to 8% of the population. Most people with fibromyalgia experience poor sleep, and sleep problems consistently predict pain seve...; Tim Vaughn Salomons. Pain. 2025-07-24 00:00:00
Understanding the untreated course of adults with chronic pain seeking psychological intervention: a systematic review and meta-analysis: The untreated course of chronic pain is not well understood, despite the importance of this information for treatment planning and benchmarking. This study examined symptom change over time and pot...; Blake F Dear. Pain. 2025-07-24 00:00:00
Physiotherapy for endometriosis-associated pelvic pain: A systematic review and meta-analysis: CONCLUSION: Physiotherapy techniques are effective in reducing pain in women with endometriosis, especially when applied locally.; Nándor Ács. Pain medicine (Malden, Mass.). 2025-07-24 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. Reviews from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

Pubmed Link