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Gait
Humans possess two primary gaits: walking and running. This article focuses on the walking gait, a complex, coordinated action requiring the seamless integration of sensory and motor functions throughout the neuromuscular and skeletal systems. A gait disturbance is defined as any deviation from a smooth, symmetrical, and efficient walking pattern. Such disturbances can affect the synchrony, fluency, and symmetry of movement. Identifying a gait disturbance is often a crucial step in diagnosing underlying pathologies, which can occur at any level of the neuraxis (central and peripheral nervous system) or within the musculoskeletal system itself. - Read More
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Differential Effects of Repetitive Transcranial Magnetic Stimulation on Mood and Pain Symptoms in People With Chronic Pain and Major Depressive Disorders—A Review
Ciampi de Andrade et al. European Journal of Pain. July 2025
ABSTRACT - Evidence shows rTMS has target- and symptom-specific effects: Motor cortex stimulation improves pain without reliably affecting mood, while dorsolateral prefrontal cortex stimulation alleviates depressive symptoms but inconsistently influences pain. These outcomes suggest that symptom improvement with rTMS is not global over different symptom clusters, but rather different for specific syndromes and the respective neural networks engaged by therapy. Personalised treatment strategies guided by pre-treatment connectivity profiles and symptom clusters, already in use for psychiatric disorders, could enhance outcomes in chronic pain management. However, limitations include small sample sizes, low session numbers and potential floor effects in studies involving non-depressed fibromyalgia patients.
“I will respect the hard-won scientific gains of those physicians in whose steps I walk, and gladly share such knowledge as is mine with those who are to follow.”
— The Hippocratic Oath: Modern Version, Lasagna 1964