Chronic Progressive External Ophthalmoplegia

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The cardinal manifestation of Chronic Progressive External Ophthalmoplegia (CPEO) is progressive extraocular weakness. In relation to Musculosokeletal Medicine, chronic pain affects the majority of those with this disorder, with the proximal lower limbs and head being the most common sites. Pain in the spine and calves are the next most common sites. Chronic fatigue and depression are also common.