Diffuse Idiopathic Skeletal Hyperostosis
Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory condition causing calcification and ossification of spinal ligaments and entheses. It is also known as ankylosing hyperostosis, Forestier disease, and Forestier-Rotes-Querol disease. The condition may be asymptomatic, or may be associated with spinal pain.
Aetiology
The cause of DISH is unknown, however it has been thought that certain factors may be important in its development. These include mechanical factors, diet, drugs, environmental exposures, and metabolic conditions. It is thought that there is abnormal osteoblastic differentiation and activity located at the entheses, as some patients may be deficient in certain inhibitors of bone formation such as Dickkopf-1 and matrix Gla protein.
- Mechanical factors
A right-sided prominence of bony bridging is seen at the thoracic spine. There may be mechanical factors associated with the location of the aorta. Interestingly, in those with dextrocardia or situs inversus, the bony bridging is more prominent on the left.
Mechanical forces may affect bone formation. In those with ossification of hte posterior longitudinal ligament (may occur with DISH or independently), ligamentous stretching can increase prostaglandin I2 synthase which results in stimulation of osteogenic differentation. Dickkopf-1, an inhibitor of osteoblastogenesis, may be reduced in those with DISH thereby promoting hyperostosis.
There does not appear to be a difference in the amount of heavy work done in those with DISH compared to controls.
- Environmental factors and diet
Fluoride has been investigated but found unlikely to be a cause. There are mixed reports of the association between higher serum retinol (signifying excessive vitamin A exposure) levels and DISH.
- Medications
Isotretinoin, which is a derivative of vitamin A, and other retinoids are associated with hyperostosis, but more-so in extraspinal areas.
- Metabolic conditions
It is thought that metabolic factors many contribute to increased osteoblastic activity in DISH. Some studies report increased levels of insulin, insulin-like growth factor 1, and growth hormone. Insulin-like growth factor 1 stimulates osteoblasts, and growth hormone can increase the production of this factor.
There are some intriguing demographic studies looking at the association between DISH and metabolic conditions. The Pima Native American people have both a high incidence of DISH and metabolic conditions such as obesity, hypertension, diabetes mellitus, and hyperinsuliaemia. DISH appears to be more common in obese Caucasian people, and possibly also in those with diabetes mellitus. DISH is also seen in up to 20 percent in acromegalic patients.
Also seen in the condition is increased vascularity of the ossified ligaments. It is not known whether this is a cause or a downstream effect of DISH.
Other factors have been studied in their role in DISH. Platelet-derived growth factor-BB and transforming growth factor-1-beta in the cells of ligaments can increase levels of nuclear factor kappa B. Nuclear factor kappa B can promote osteoblastogenesis. Curiously, there are elevated levels of matrix Gla in DISH, but this protein is thought to inhibit bone formation.
Epidemiology
DISH is more common in men than woman, and it is rare under the age of 40.
There are some demographic variations. In Japan, ossification of the posterior longitudinal ligament, mainly in the cervical spine, is 80 time more common than in Europe at 4%. American blacks have lower levels of DISH than whites. The Pima Native American people can develop DISH young, rising to 48% in men and 12% in women in those over 55 years old. In Finland the prevalence is 3.8% in men and 2.6% in women in those over 40. In Hungary the prevalence is 4.9% in men and 1.4% in women over age 50. Studies done in hospitals find a higher prevalence of DISH than the general population.
Clinical Features
Patients with DISH may have pain in the neck, thoracic spine, low back, and/or the extremities. Thoracic spine involvement is present universally in advanced cases. There may be reduced spinal mobility. Myelopathy has been reported to occur in some individuals. Dysphagia and airway obstruction can also occur. It is unclear whether it is associated with other musculoskeletal or systemic diseases. Most studies on clinical features are done in patients seen in clinics and the hospital, and so are more likely to have symptoms.
Morning spinal stiffness is present in around 80% of individuals, which is a symptoms normally associated with inflammatory conditions. Higher pain levels are seen in those with DISH compared to "lumbar spondylosis" and healthy controls. Disability scores are also higher in DISH compared to healthy controls, and patients may reports difficulty bending and having weak grip strength. Men are less likely to complete five chair stands without using their arms.
Radicular pain and lumbar spinal stenosis are not a typical features of DISH, and if present it may be unrelated.
Pain in the thoracic spine is the most common symptoms and occurs in 40 to 80% of subjects. Pain in the extremities and dysphagia are less common, reported in 15 to 25%. Stridor is a rare symptom resulting from large C2 to C3 anterior osteophytes. This may cause odynophagia and otalgia due to hypopharyngeal ulceration from the pressure. There is an increased risk of dysphagia, due to compression of the oesophagus from anterior cervical osteophytes. Other manifestations of cervical disease are hoarseness, aspiration pneumonia, sleep apnoea, atlantoaxial subluxation or pseudoarthrosis, and thoracic outlet syndrome.
There are mixed reports on the association between radiologic findings and symptoms at that site. There appears to be a significant association between shoulder hyperostosis and shoulder symptoms, as well as a non-significant association between elbow hyperostosis and elbow symptoms. Meanwhile there is no apparent link between spinal hyperostosis and spinal pain. In those with DISH and chronic low back pain, there is also a non-significant increase in media epicondylitis, knee enthesitis, plantar fasciitis, and dysphagia, compared to patients with "lumbar spondylosis."
