EBQ:SPACE Trial: Difference between revisions
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==Clinical Question== | ==Clinical Question== | ||
==Bottom Line== | ==Bottom Line== | ||
A landmark study was published in 2018 by Krebs et al - the SPACE study. It was a pragmatic randomised controlled trial comparing opioid versus non opioid analgesics for 12 months in primary care. Participants were 240 VA patients with moderate to severe chronic back pain or knee/hip OA, and not on opioids. The mean pain intensity initially was 5.4 in both arms. Pain scores at 1 year was worse in the opioid arm (4.0) than non opioid (3.5) (P=0.034). There was no difference in pain interference, and adverse effects were worse in opioid group (P=0.03).<ref name="SPACE"/> | |||
<gallery mode="nolines" widths=350px heights=250px> | |||
File:SPACE BPI 2018.png|Brief Pain Inventory (BPI) over 12 months | |||
File:SPACE BPI interference 2018.png|Pain Interference over 12 months | |||
</gallery> | |||
==Study Design== | ==Study Design== | ||
==Population Studied== | ==Population Studied== |
Revision as of 18:05, 3 April 2021
Krebs et al.. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial. JAMA 2018. 319:872-882. PMID: 29509867. DOI. Full Text.
Clinical Question
Bottom Line
A landmark study was published in 2018 by Krebs et al - the SPACE study. It was a pragmatic randomised controlled trial comparing opioid versus non opioid analgesics for 12 months in primary care. Participants were 240 VA patients with moderate to severe chronic back pain or knee/hip OA, and not on opioids. The mean pain intensity initially was 5.4 in both arms. Pain scores at 1 year was worse in the opioid arm (4.0) than non opioid (3.5) (P=0.034). There was no difference in pain interference, and adverse effects were worse in opioid group (P=0.03).[1]
Study Design
Population Studied
Inclusion Criteria
Exclusion Criteria
Baseline Characteristics
Interventions
Outcomes/Results
Primary Outcomes
Secondary Outcomes
Adverse events
Discussion
Criticism
Funding
See Also
- ↑ Cite error: Invalid
<ref>
tag; no text was provided for refs namedSPACE