Neuropathic Pain

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The IASP defines neuropathic pain as pain that is caused by a lesion or disease of the somatosensory system. The pathophysiology involves a complex and redundant interplay of neural generators, circuits, and mediators. Neuroanatomical changes consist of both peripheral and central adaptive and maladaptive mechanisms. The adaptive processes include changes in pro-nociceptive and anti-nociceptive systems.