Nociplastic Pain
Epidemiology
The prevalence of chronic pain in New Zealand, when defined as lasting for 6 months or longer, was measured at 16.9% in 2011. Prevalence increased with age and economic deprivation. Pacific and Asian peoples had lower rates of chronic pain than European/other.[1] Around one fifth of people with chronic pain have predominantly neuropathic pain.[citation needed] Neuropathic pain is more disabling than other forms of pain and is associated with a lower quality of life.[citation needed]
Definitions
The IASP definitions of pain can be found on their website.
- IASP Definition of Pain
The IASP definition of pain was recently updated in 2020.[2]
“An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage”
—IASP Definition of Pain 2020
- Central Sensitisation
Woolf discussed the differences between pain versus pathology versus "pain syndromes."[3] The central component of post-injury pain hypersensitivity was first termed sensitisation in 1987.[4]
“Any sensory experience greater in amplitude, duration and spatial extent than that would be expected from a defined peripheral input under normal circumstances qualifies as potentially reflecting a central amplification due to increased excitation or reduced inhibition. These changes could include a reduction in threshold, exaggerated response to a noxious stimulus, pain after the end of a stimulus, and a spread of sensitivity to normal tissue”
—Woolf 2011
The IASP define central sensitisation as follows:
“Increased responsiveness of nociceptive neurons in the central nervous system to their normal or subthreshold afferent input.”
—IASP
- Nociceptive Pain
actual or threatened damage , non-neural tissue, activation of nociceptors.
- Neuropathic pain
Primary lesion or disease of the somatosensory nervous system.
Key Articles
- {{#l:Cohen2016 - nociplastic pain third mechanistic descriptor.pdf}}
- {{#l:Woolf2011 - Central sensitisation.pdf}}
- {{#l:Woolf2014 - Nociceptive amplification naming.pdf}}
- {{#l:Yunus2008 - Central sensitivity syndrome.pdf}}
References
- ↑ Dominick et al.. Patterns of chronic pain in the New Zealand population. The New Zealand medical journal 2011. 124:63-76. PMID: 21946879.
- ↑ International Association for the Study of Pain (2020) IASP’s New Definition of Pain. Available at: https://www.iasp-pain.org/PublicationsNews/NewsDetail.aspx?ItemNumber=10475 (accessed 27 July 2020).
- ↑ Woolf. Central sensitization: implications for the diagnosis and treatment of pain. Pain 2011. 152:S2-15. PMID: 20961685. DOI. Full Text.
- ↑ Woolf et al.. Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro. Journal de physiologie 1988. 83:255-66. PMID: 3272296.
