Notalgia Paraesthetica: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
{{ | {{Partial}} | ||
Notalgia paresthetica (NP) is a chronic cutaneous sensory neuropathy that causes localized [[Histamine|pruritus]] and associated dysesthesias, such as pain, numbness, and tingling in the thoracic spine. | |||
Ā | |||
== Pathophysiology == | |||
The precise pathophysiology underlying NP is yet to be fully elucidated. However, a prominent hypothesis suggests that degenerative changes in the spine or musculoskeletal compression leads to impingement of the posterior cutaneous branches of T2-T6 spinal nerves, which subsequently causes a thoracic polyradiculopathy and contributes to the pathogenesis of NP. It is believed that this impingement results in damage to the spinal nerves mentioned above. Patients with NP are more likely to have degenerative cervical and thoracic spine disease than those with back pain without pruritis<ref name=":0">{{Cite journal|last=Robinson|first=Christopher|last2=Downs|first2=Evan|last3=De la Caridad Gomez|first3=Yanet|last4=Nduaguba|first4=Chinonso|last5=Woolley|first5=Parker|last6=Varrassi|first6=Giustino|last7=Gill|first7=Jatinder|last8=Simopoulos|first8=Thomas T.|last9=Viswanath|first9=Omar|last10=Yazdi|first10=Cyrus A.|date=2023-02-19|title=Notalgia Paresthetica Review: Update on Presentation, Pathophysiology, and Treatment|url=https://pubmed.ncbi.nlm.nih.gov/36826171|journal=Clinics and Practice|volume=13|issue=1|pages=315ā325|doi=10.3390/clinpract13010029|issn=2039-7275|pmc=9955802|pmid=36826171}}</ref> | |||
Ā | |||
== Epidemiology == | |||
The condition has a predilection for those in their middle age and affects women 2 to 3 times more often than men.<ref name=":0" /> | |||
Ā | |||
== Clinical Features == | |||
This condition is characterized by hyperpigmentation and chronic scratching and rubbing in the thoracic spine. Typically, the symptoms are unilateral and located in the middle or upper back, medial or inferior to the scapula between T2 to T6. | |||
Ā | |||
NP can last for years, with periods of remission and exacerbation. It primarily affects adults, especially women, but hereditary cases have also been reported in younger patients associated with multiple endocrine neoplasia type 2A (MEN 2A). | |||
== Resources == | == Resources == | ||
{{PDF|Notalgia Paresthetica - Situm 2018.pdf}} | {{PDF|Notalgia Paresthetica - Situm 2018.pdf}} | ||
{{PDF|Notalgia Paresthetica - Robinson 2023.pdf}} | {{PDF|Notalgia Paresthetica - Robinson 2023.pdf}} | ||
== References == | |||
<references/> | |||
{{Reliable sources|synonym1=notalgia paresthetica}} | {{Reliable sources|synonym1=notalgia paresthetica}} | ||
[[Category:Polyneuropathies]] | [[Category:Polyneuropathies]] | ||
[[Category:Thoracic Spine Conditions]] | [[Category:Thoracic Spine Conditions]] |
Revision as of 13:29, 12 March 2023
Notalgia paresthetica (NP) is a chronic cutaneous sensory neuropathy that causes localized pruritus and associated dysesthesias, such as pain, numbness, and tingling in the thoracic spine.
Pathophysiology
The precise pathophysiology underlying NP is yet to be fully elucidated. However, a prominent hypothesis suggests that degenerative changes in the spine or musculoskeletal compression leads to impingement of the posterior cutaneous branches of T2-T6 spinal nerves, which subsequently causes a thoracic polyradiculopathy and contributes to the pathogenesis of NP. It is believed that this impingement results in damage to the spinal nerves mentioned above. Patients with NP are more likely to have degenerative cervical and thoracic spine disease than those with back pain without pruritis[1]
Epidemiology
The condition has a predilection for those in their middle age and affects women 2 to 3 times more often than men.[1]
Clinical Features
This condition is characterized by hyperpigmentation and chronic scratching and rubbing in the thoracic spine. Typically, the symptoms are unilateral and located in the middle or upper back, medial or inferior to the scapula between T2 to T6.
NP can last for years, with periods of remission and exacerbation. It primarily affects adults, especially women, but hereditary cases have also been reported in younger patients associated with multiple endocrine neoplasia type 2A (MEN 2A).
Resources
References
- ā 1.0 1.1 Robinson, Christopher; Downs, Evan; De la Caridad Gomez, Yanet; Nduaguba, Chinonso; Woolley, Parker; Varrassi, Giustino; Gill, Jatinder; Simopoulos, Thomas T.; Viswanath, Omar; Yazdi, Cyrus A. (2023-02-19). "Notalgia Paresthetica Review: Update on Presentation, Pathophysiology, and Treatment". Clinics and Practice. 13 (1): 315ā325. doi:10.3390/clinpract13010029. ISSN 2039-7275. PMC 9955802. PMID 36826171.
Literature Review
- Reviews from the last 7 years: review articles, free review articles, systematic reviews, meta-analyses, NCBI Bookshelf
- Articles from all years: PubMed search, Google Scholar search.
- TRIP Database: clinical publications about evidence-based medicine.
- Other Wikis: Radiopaedia, Wikipedia Search, Wikipedia I Feel Lucky, Orthobullets,