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  • 18:04, 19 May 2023 Jeremy talk contribs uploaded File:Sodium channel alpha subunit.jpg (Li ZM, Chen LX, Li H. Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go? Curr Med Sci. 2019 Dec;39(6):863-873. doi: 10.1007/s11596-019-2117-0. Epub 2019 Dec 16. Erratum in: Curr Med Sci. 2020 Dec;40(6):1206. PMID: 31845216. Voltage-gated sodium (Nav) channel α-subunit topology The α-subunit contains four homologous domains (I–IV) connected by intracellular linkers, each developed by α-helical transmembrane segments (S1–S6). Voltage- sensing domain (VSD) is consti...)