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- WikiMSK:Featured Article/1 May 2023 + (Small fiber neuropathy (SFN) is a painful … Small fiber neuropathy (SFN) is a painful neuropathy involving selectively the Aδ and C nerve fibres. This leads to sensory, autonomic, or combined symptoms. Small fibre neuropathy (SFN) and large fibre neuropathy belong to a group of diseases known as peripheral neuropathies. Polyneuropathy refers to cases where either the large fibres are affected, or both the large and small fibres are affected. SFN refers to isolated small fibre involvement. About 40-50% of patient with fibromyalgia meet the diagnostic criteria for SFNalgia meet the diagnostic criteria for SFN)