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- WikiMSK:Featured Article/1 May 2022 + (Thoracic outlet syndrome (TOS) is caused b … Thoracic outlet syndrome (TOS) is caused by compression of the brachial plexus or subclavian vessels as they pass through the narrow passageways leading from the base of the neck to the axilla and arm. There is considerable disagreement about its diagnosis and treatment, particularly the neurogenic form. Practice guidelines are not currently possible due to the low level of evidence.possible due to the low level of evidence.)