Template:Lower Limb Pain Neurogenic and Referred DDX

• Systemic Conditions
  • Metabolic Neuropathy
    • Diabetes Mellitus with distal symmetrical polyneuropathy
    • Diabetes Mellitus of other subtypes - proximal diabetes, truncal, cranial, median and ulnar neuropathies
    • Diabetes Mellitus with autonomic neuropathy
    • Diabetic amyotrophy Probably a vasculitis aetiology with ischaemia followed by axonal degeneration and demyelination. Characterised by unilateral weakness, wasting, and pain, commonly in the quadriceps, then spreading later to the contralateral side asymmetrically.
  • Vasculitis Neuropathy vasculitis of the small and medium-sized vessels in the peripheral nervous system.
    • Primary vasculitides: Churg-Strauss syndrome, microscopic polyangiitis, classic polyarteritis nodosa and Wegener granulomatosis
    • Secondary vasculitides: A complication of connective tissue disease (systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome), infection (hepatitis B and C, human immunodeficiency virus, Lyme disease, cytomegalovirus, Herpes zoster virus and various bacterial infections), medication (sulphonamides, other antibiotics and anti-viral agents) and paraneoplastic vasculitis