Proximal Weakness

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Classification

Proximal Weakness

Myopathic

Non-Myopathic

Acquired

Genetic

Inflammatory myositis Polymyositis dermatomyositis immune mediated necrotising myopathy Endocrine - e.g cushings, dysthyroid Drugs Hyper/hypokalaemia

Becker's or Duchenne's muscular dystrophy Limb girdle muscle dystrophies Congenital myopathies Mitochondrial Metabolic (glycogen or lipid disorder) Acid maltase

Peripheral neuropathies with proximal weakness - vasculitis or CIDP Plexopathies e.g. diabetic amyotrophy Infiltration nerve root - neoplastic meningitis Myelopathy Neuromuscular junction - Lambert Eaton myaesthenic syndrome Anterior horn cell - spinal muscular atrophies if chronic, motor neuron disease if subacute and progressive