Widespread Pain Differential Diagnoses

• Autoimmune: Polymyalgia Rheumatica, Sjogren's Disease, Rheumatoid Arthritis, Connective tissue disease (autoimmune), Inflammatory myositis, Sarcoidosis, Celiac disease, Inflammatory Bowel Disease, Sarcoidosis
• Genetic: Heritable Connective Tissue Disorders, Neuromuscular Diseases (e.g. Myotonic Dystrophy type 2, Pompe Disease)
• Idiopathic: Fibromyalgia, Degenerative myopathies, Small Fibre Neuropathy
• Primary Joint disease: Osteoarthritis
• Neoplastic disease: Metastases, Multiple myeloma, Leukaemia, Lymphoma
• Infections: bacterial endocarditis, hepatitis B and C
• Bone disease: Osteomalacia, Osteomyelitis
• Endocrine: Hypothyroidism and hyperthyroidism, Hyperparathyroidism, Acromegaly, Diabetes, Vitamin D deficiency, endocrine myopathies
• Neurological: Parkinson disease, Neuropathies, Motor neurone disease, Chronic Inflammatory Demyelinating Polyneuropathy, Multiple sclerosis, Myalgias in rare disease (e.g., Stiff Person Syndrome), Myalgias with lesions of the central and peripheral nervous system
• Medication: opioids, statins, aromatase inhibitors, carbimazole, ezitimibe, metoprolol, minoxidil, PPIs, salbutamol, amiodarone, colchicine, ACE inhibitors