Familial Episodic Pain Syndrome

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Familial Episodic Pain Syndrome
Inheritance Heterozygous
Genetics FEPS type I - TRPA1, activating

FEPS type II - SCNA10A, activating
FEPS type III - SCN11A (Nav1.9), activating

Familial episodic pain syndrome (FEPS) encompasses a group of non-inflammatory, paroxysmal pain syndromes primarily affecting the distal extremities. These syndromes can be classified into three types based on the pathogenic gene involved: FEPS1, caused by transient receptor potential cation channel (TRPA1) gene mutation; FEPS2, due to sodium voltage-gated channel alpha subunit 10A (SCN10A) gene mutation; and FEPS3, resulting from sodium voltage-gated channel alpha subunit 11A (SCN11A) gene mutation.


See Also

Channelopathies and Chronic Pain

Sodium Channelopathies

Literature Review