Foot Drop Differential Diagnoses

From WikiMSK

Unilateral Foot Drop

  • Deep peroneal neuropathy
  • Common peroneal neuropathy
  • Anterior compartmental syndrome of the leg
  • Sciatic neuropathy
  • Lumbosacral plexopathy (lumbosacral trunk)
  • L5 radiculopathy
  • L4 radiculopathy (rarely)
  • Conus medullaris lesion (rarely)
  • Multifocal motor neuropathy (usually peroneal)
  • Vasculitic neuropathy (usually peroneal)
  • Hereditary Neuropathy with liability to Pressure Palsies (HNPP)a
  • Amyotrophic lateral sclerosis
  • Poliomyelitis and postpoliomyelitis syndrome
  • Cortical or subcortical parasagittal cerebral lesion

Bilateral Foot Drop

  • Myopathies
    • Distal myopathies (including distal forms of LGMD)
    • Scapuloperoneal muscular dystrophy
    • Facioscapulohumeral muscular dystrophy
    • Myotonic dystrophy
  • Neuropathies
    • Multifocal motor neuropathy with conduction block
    • Hereditary neuropathy with liability to pressure palsy (HNPP)
    • Chronic inflammatory demyelinating polyneuropathy (CIDP)
    • Bilateral peroneal neuropathies
    • Bilateral sciatic neuropathies (rare)
    • Bilateral lumbosacral plexopathies (rare)
    • Vasculitic neuropathy
  • Radiculopathies
    • Bilateral L5 radiculopathies (cauda equina lesion)
    • Conus medullaris lesion
    • Anterior horn cell disorders
    • Amyotrophic lateral sclerosis
    • Poliomyelitis and the postpoliomyelitis syndrome
  • Cerebral lesions
    • Bilateral cortical or subcortical parasagittal lesions