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From WikiMSK
Featured Open Access Journal Article for 1 November 2024
Open-Label Placebo Injection for Chronic Back Pain With Functional Neuroimaging
JAMA Psychiatry
ABSTRACT - In this randomized clinical trial of 101 adults with chronic back pain, an open-label subcutaneous placebo (saline) injection led to significant improvements in pain intensity, mood, and sleep at 1 month posttreatment compared with usual care. The placebo treatment also led to reduced somatomotor activity and increased medial prefrontal activity during evoked back pain and to increased medial prefrontal-brainstem functional connectivity during spontaneous pain.
