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Latest RCTs

A within-subject, double-blind, placebo-controlled randomized evaluation of the combined effects of cannabidiol and hydromorphone in a human laboratory pain model: Preclinical and epidemiological evidence supports that cannabinoids may have opioid-sparing properties and could be one strategy to decrease opioid use and associated harms like overdose and extram...; Kelly E Dunn. Pain. 2025-08-21 00:00:00
Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial: Our group has shown that translocator protein (TSPO) levels, a putative marker of neuroinflammation, are increased in the brain and spinal cord of patients with chronic low back pain (cLBP). Whethe...; Marco L Loggia. Pain. 2025-08-21 00:00:00
Moderators of digital cognitive-behavioral therapy for youth with sickle cell disease pain: secondary analysis of a randomized controlled trial: Pain is the hallmark symptom of sickle cell disease (SCD). By adolescence, 20% of youth with SCD develop chronic SCD pain. Our randomized controlled trial found significant reductions in pain in yo...; Jennifer N Stinson. Pain. 2025-08-21 00:00:00
Effects of Dexamethasone Administration in Sphenopalatine Ganglion Block for Allergic Rhinitis: A Prospective, Randomized, Single-blind Controlled Trial: CONCLUSIONS: Ultrasound-guided SPGB is a safe and effective treatment for AR, improving symptoms, quality of life, and nasal airflow. The addition of corticosteroids may enhance short-term efficacy.; Lijuan Lu. Pain physician. 2025-08-07 00:00:00
Atelocollagen vs. Prolotherapy in Partial-Thickness Supraspinatus Tears: A Prospective Randomized Controlled Trial with MRI-Confirmed Outcomes: CONCLUSIONS: In patients with PTSTs, atelocollagen injections provided more efficient pain relief and demonstrated greater structural improvements than did prolotherapy, as confirmed by MRI. While ...; Pyung Bok Lee. Pain physician. 2025-08-07 00:00:00
Self-Chosen Music as a Contributor to Music-Induced Analgesia Across Diverse Socio-Cultural Backgrounds: A Crossover Randomised Controlled Trial: CONCLUSIONS: Listening to self-chosen music was effective in MIA, irrespective of socio-cultural background or type of music. In contrast, researcher-chosen (classical) music was most effective in ...; Markus Klimek. European journal of pain (London, England). 2025-08-07 00:00:00
Effectiveness of Equimolar Mixture of Oxygen and Nitrous Oxide Combined With Audiovisual in Young Children: A Randomised Controlled Trial: CONCLUSION: The combination of audiovisuals with EMONO may be effective in increasing cooperation and reducing pain in children 2-5 years during PVC placement.; Valeria Carla Edefonti. European journal of pain (London, England). 2025-08-05 00:00:00
Alcohol-Induced Disinhibition of Facial Responses to Pain: BACKGROUND: Alcohol in sub-toxic dosages has appeared to slightly reduce experimental pain in psychophysical paradigms. However, this effect may also reflect impaired scaling performance in subject...; Miriam Kunz. European journal of pain (London, England). 2025-08-02 00:00:00
It Is Time to Feel Better: How Temporal Information of Placebo Analgesia Affects Our Brain: CONCLUSION: This study proposes that the cortical network related to the placebo effect may be active and modulated by temporal information of cream effectiveness, as well as their behavioural resp...; Carlino Elisa. European journal of pain (London, England). 2025-08-01 00:00:00
Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS): CONCLUSIONS: This study elucidates how CRPS affects cognitive functioning, important information when tailoring multidisciplinary rehabilitation to CRPS patients. Psychological factors may have a s...; E Kalso. European journal of pain (London, England). 2025-07-08 00:00:00
Cluster-Randomised Controlled Trial of At-Home Virtual Reality for People With Chronic Musculoskeletal Pain on the Waiting List: BACKGROUND: Virtual reality (VR) has been introduced as a novel intervention in chronic musculoskeletal pain (CMP) rehabilitation. However, much remains unknown about the effectiveness of VR for CM...; Monique Tabak. European journal of pain (London, England). 2025-07-05 00:00:00
Attentional Focus but Not Distraction or Expectations Influence Conditioned Pain Modulation in Healthy Adults: CONCLUSIONS: Since attentional focus on the CS reduces CPM efficacy, it is recommended to not rate the CS pain intensity during CS application to prevent a reduction of the inhibitory effect. Furth...; Jessica Van Oosterwijck. European journal of pain (London, England). 2025-06-21 00:00:00
Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled Trial: CONCLUSION: The results indicated that neuromuscular exercise combined with PNE significantly reduced TSP at the index knee, suggesting a reduction in central pain amplification. The clinical impor...; Lars Arendt-Nielsen. European journal of pain (London, England). 2025-06-20 00:00:00
Are self-reported exercise adherence measures associated with pain and function outcomes among participants receiving treatment for Achilles tendinopathy? A secondary analysis of a randomised contr...: CONCLUSION: Although adherence to frequency of exercise is commonly assessed in the literature, it was not associated with clinical outcomes in people with Achilles tendinopathy performing a 12-wee...; Peter Malliaras. Musculoskeletal science & practice. 2025-06-10 00:00:00
Could the Hanging Drop Technique Be an Alternative Method to Loss of Resistance in Cervical Epidural Injections?: CONCLUSIONS: The LOR technique was superior to the HD for cervical ILESIs. More studies with larger sample sizes may provide more precise and detailed information.; Hamit Goksu. Pain physician. 2025-06-04 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. RCTs from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

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Latest Systematic Reviews

Corrections to "Aerobic Exercise Prescription for Pain Reduction in Fibromyalgia: A Systematic Review and Meta-Analysis": No abstract; . European journal of pain (London, England). 2025-08-28 00:00:00
Accuracy and Efficacy of Ultrasound Guided Glenohumeral Joint Injections: A Systematic Review: CONCLUSION: Ultrasound-guided glenohumeral joint injections are more accurate than landmark guided injections and have similar accuracy rates compared to other imaging modalities. Ultrasound-guided...; Nitin B Jain. American journal of physical medicine & rehabilitation. 2025-08-26 00:00:00
Effectiveness of Genicular Nerve Radiofrequency Ablation in Osteoarthritis and Post-surgical Knee Pain: Systematic Review: CONCLUSIONS: GnRFA is effective in reducing knee pain in the majority of patients with osteoarthritis when large lesion techniques are used with moderate-certainty evidence, according to GRADE. Alt...; Reza Ehsanian. Pain medicine (Malden, Mass.). 2025-08-26 00:00:00
Effectiveness of Movement Representation Strategies in Knee Pain: A Systematic Review and Meta-Analyses on Knee Pain and Function: INTRODUCTION: A highly prevalent condition, knee pain often results in significant functional limitations and a reduced quality of life. Due to its multifactorial causes and diverse pathologies, nu...; Marie Carmen Valenza. European journal of pain (London, England). 2025-08-25 00:00:00
Evidence-Based Framework for Identifying Opioid Use Disorder in Administrative Data: A Systematic Review and Methodological Development Study: CONCLUSIONS: An evidence-based framework incorporating diagnosis codes, specific temporal requirements, validated indirect indicators, and treatment evidence provides theoretical foundation for sta...; Meredith C B Adams. Pain medicine (Malden, Mass.). 2025-08-25 00:00:00
Role of stretching interventions in enhancing the shoulder range of motion in overhead athletes with glenohumeral internal rotation deficit: A systematic review and meta-analysis: CONCLUSION: SS or combination of SS and CS interventions significantly enhanced the ROM of IR compared to the control group in overhead athletes diagnosed with GIRD. Furthermore, the review confirm...; Omar A Selim. PM & R : the journal of injury, function, and rehabilitation. 2025-08-22 00:00:00
A systematic review and meta-analysis of pharmacological methods to manipulate experimentally induced secondary hypersensitivity: Understanding the physiology of specific clinical features of persistent pain, such as secondary hypersensitivity, is crucial for developing effective treatments. This systematic review and meta-an...; Victoria J Madden. Pain. 2025-08-21 00:00:00
Regarding chronic pain in European adult populations: a systematic review of prevalence and associated clinical features by Rometsch, Caroline et al: No abstract; Michele Sterling. Pain. 2025-08-21 00:00:00
The Effectiveness of School-Based Interventions on Pain and Disability Outcomes in Adolescents With Persistent Pain. A Systematic Review: CONCLUSION: Relaxation and exercise showed promising effectiveness on reducing persistent pain in adolescents, although with a high risk of bias. The need for higher-quality studies remains imperat...; Britt Elin Øiestad. European journal of pain (London, England). 2025-08-15 00:00:00
Reliability of Temporal Summation of Pain in Healthy and Clinical Populations: A Systematic Review and Meta-Analysis: CONCLUSION: TSP demonstrates moderate reliability, influenced by stimulus parameters and population. Small-area mechanical stimuli (e.g., pinprick), tested at 1 Hz using absolute change scores, yie...; Rutger Marinus Johannes de Zoete. European journal of pain (London, England). 2025-08-08 00:00:00
Preemptive Acetaminophen for Postoperative Analgesia in Children Undergoing Surgery: A Systematic Review and Meta-Analysis: CONCLUSION: Preemptive acetaminophen in pediatric patients could effectively alleviate postoperative pain and decrease the need for additional rescue analgesic interventions.; Wei-Bing Tang. Pain physician. 2025-08-07 00:00:00
A Systematic Review And Meta-Analysis Of Randomized Trials Of Therapeutic Intraarticular Facet Joint Injections In Chronic Axial Spinal Pain: CONCLUSION: Based on qualitative analysis and GRADE assessment, intraarticular facet joint injections are supported by Level IV evidence, with limited quality, low certainty, and a low strength of ...; Joshua A Hirsch. Pain physician. 2025-08-07 00:00:00
Exercise Therapy Versus Manual Therapy for the Management of Pain Intensity, Disability, and Physical Function in People With Chronic Low Back Pain: A Systematic Review With Meta-Analysis and Meta-...: CONCLUSIONS: ET had a small beneficial effect on long-term disability in people with CLBP. Nevertheless, evidence does not provide conclusive differences between both the treatments overall, influe...; Álvaro-José Rodríguez-Domínguez. European journal of pain (London, England). 2025-08-01 00:00:00
Four MBE Therapies to Improve Pain Scores, Physical Functioning, and Quality of Life in Patients With Chronic Nonspecific Low Back Pain: Network Meta-Analysis of Randomised Controlled Trials: CONCLUSION: QG is the most effective for pain relief and improving physical function, while TC best enhances QoL. Different MBEs have distinct effects on functional outcomes, suggesting that interv...; Rui Huang. European journal of pain (London, England). 2025-07-31 00:00:00
Accuracy and Efficacy of Intra-Articular Knee Injections/Aspirations Under Ultrasound versus Landmark Guidance: A Systematic Review: CONCLUSIONS: This systematic review provides data to support that US-guided intra-articular knee injections/aspirations are more accurate and efficacious than LM-guided intra-articular knee injecti...; Nitin B Jain. American journal of physical medicine & rehabilitation. 2025-07-29 00:00:00

If anyone is good at writing pubmed searches then please help out with improving this section. Reviews from: Pain, Pain physician, Pain Medicine, European journal of pain, Musculoskeletal science practice, American journal of PM & R, PM & R, Spine, European spine journal, The spine journal

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