Transitional Vertebral Anatomy
The most common vertebral arrangement is of 24 presacral vertebrae, consisting of 7 cervical, 12 thoracic, and 5 lumbar vertebrae; and 5 sacral vertebrae (7C-12T-5L-TS). The cervical spine has a fixed vertebral count of 7, however the lumbar and thoracic vertebrae counts can be variable resulting in 23, 24, or 25 presacral vertebrae. It is termed "vertebral trade-off" when there is transitional anatomy but the total thoracolumbar count remains the same.
It is important to accurately describe transitional anatomy as failing to do so can lead to surgery or interventions done at the incorrect level, and it can confound the neurological examination with variations in the myotomes.
Transitional vertebrae occur when there is overlap of developing somites during cranial-caudal border shifting. The vertebrae affected have morphology of a combined nature of the two adjacent vertebral regions.
In development there are specific interactions between the vertebrae and spinal nerves, and the Hox genes are involved in the regulation of their development.
- Lumbosacral Transitional Anatomy
- Lumbarisation of S1 occurs in around 2% of the population. Sacralisation of L5 occurs in around 17% of the population.
- In a study of 147 subjects, 24 (16.3%) had lumbosacral transitional anatomy, 16 (10.9%) had an anomalous number of vertebrae. Having a lumbosacral transitional vertebra was associated with a 7.4 times odds of having an anomalous number of presacral segments
- 135 (~92%) had 24 segments.
- 131 (~97%) had 12 thoracic and five lumbar vertebrae ("normal")
- 3 (~2%) had 13 thoracic and four lumbar vertebrae
- 1 (~1%) had 11 thoracic and six lumbar vertebra
- 7 (~5%) had 23 segments
- 2 (~30%) had 12 thoracic and four lumbar vertebrae ("L5 sacralisation").
- 5 (~70%) had 11 thoracic and five lumbar
- 5 (~4%) had 25 segments.
- 4 (80%) had 12 thoracic and six lumbar vertebrae ("S1 lumbarisation").
- 1 (20%) had 13 thoracic and five lumbar vertebrae
- 135 (~92%) had 24 segments.
- Thoracolumbar transitional anatomy prevalence was 4% in one study. Thoracolumbar and lumbosacral transitional vertebrae were associated with each other. 
- Cervical ribs occur in around 0.2 to 0.5% of the population
Differences in total thoracolumbar counts may be more common in women (i.e. 16 or 18 thoracolumbar vertebrae).
Lumbosacral Transitional Anatomy
|TV Location||Vertebral Segments||Anatomical Features||Nerve Root Changes|
|L5 sacralisation||4 rib-free lumbar vertebrae||wedging of the lowest lumbar (transitional) vertebra
hypoplastic or absent facet joints or intervertebral disc
|The L4 nerve root may serve the usual function of the L5 nerve root*.|
|S1 lumbarisation||6 rib-free lumbar vertebrae||squaring of highest sacral (transitional) vertebra
facet joints (even rudimentary) and intervertebral disc between S1 and S2
|The S1 nerve root may serve the usual function of the L5 nerve root*.|
|*The functional L5 nerve root may originate at the lowest mobile lumbosacral level.|
Vertebral Enumeration Technique
It can be difficult to establish whether a LSTV is a lumbarised S1 or a sacralised L5, and there have been various techniques described, with the best technique being high quality imaging of the entire spine. MRI reports should state the method of numbering and how the LSTV was determined.
Survey sequences: In New Zealand, some private radiology providers will do a sagittal survey sequence of the entire spine (also called a sagittal localiser) as routine while others do not. You then count from the odontoid peg of C2 inferiorly, rather than counting cranially from L5. One can identify the L1 vertebral body, and subsequently determine the correct numeric assignment of the LSTV. Radiographs of the entire spine can fulfil the same purpose. If there is only a normal lumbar spine radiograph, then correct numeration may still be possible, but it can be tricky at the thoracolumbar junction to differentiate the hypoplastic rib from the transverse process. Thoracolumbar transitions can also make things difficult without a full spine view.
Using a sagittal localiser sequence assumes there are 7 cervical and 12 thoracic vertebra. The method does not account for thoracolumbar transitional anatomy or allow one to differentiate between dysplastic ribs and lumbar transverse processes. Adding a coronal localising sequence can sometimes increase the accuracy of locating the thoracolumbar junction.
Iliolumbar ligament: Locating the iliolumbar ligament is another technique described. This ligament is present at the L5 transverse process in 96.8% of people. On MRI it is a low signal intensity structure on T1 and T2 images and looks like a single or double band that extends from the transverse process of L5 to the posteromedial iliac crest. It serves to restrict flexion, extension, axial rotation, and lateral bending of L5 on S1. As with other landmarks, identification of the iliolumbar ligament is not sufficient to identify the L5 vertebral body, but it can be used to identify the lumbosacral junction as it identifies the lowest lumbar type vertebral segment.
Fluoroscopic observation: On fluoroscopy, count from the up-sloped T1 transverse process. The transverse processes of C7 are longer than the transverse processes of the other cervical vertebra, but shorter than T1. The transverse processes of C7 slope downwards compared to the upsloping T1 processes.
Other anatomic markers: Using other markers such as the aortic bifurcation, right renal artery, and conus medullaris has also been described and are not satisfactory.
Other features: The lumbarised S1 may be squared and have facet joints and an intervertebral disc. The sacralised L5 may be wedged and have hypoplastic or absent jacet joints or intervertebral disc.
|Type Ia||A unilateral TP height greater than or equal to 19 mm|
|Type Ib||Both processes heights greater than or equal to 19 mm|
|Type IIa||Presence of unilateral articulation between the TP and the sacrum|
|Type IIb||Presence of bilateral articulation between the TP and the sacrum|
|Type IIIa||Unilateral fusion of the TP and the sacrum|
|Type IIIb||Bilateral fusion of the TP and the sacrum|
|Type IV||Unilateral type II transition (articulation) with a type III (fusion) on the contralateral side|
Bertolotti syndrome, the association between low back pain and LSTV, is controversial. A LSTV is certainly present in large numbers of asymptomatic people, but may be more common in those with back pain. Pain associated with LSTV is currently thought to arise from various different structures
- Disc, spinal canal, and the posterior elements above the transition.
- Degenerative change of the LSTV articulation
- Facet joint arthrosis contralateral to the unilateral fused or articulating LSTV
- Extraforaminal stenosis secondary to a broadened transverse process.
The implicated segments are normally types II-IV. However it is thought that type I segments with their broadened transverse processes and broadened and short iliolumbar ligaments may lead to a protective effect of the L5-S1 disc space and possibly destabilise the L4-5 level.
Theoretically the LSTV will alter the biomechanics of the spine, and cause some stabilisation at this level. Structural pathology (disc integrity and spinal and foraminal stenosis) occurs almost exclusively at the level above the transitional segment, and never between the LTSV and the sacrum, with normal bright signal intensity on T2 weighted sequences on MRI at the LSTV. The level above the LSTV may be hypermobile at the ipsilateral anomalous articulation and/or the contralateral facet joint. Potentially relevant is that the iliolumbar ligaments above an LSTV are thinner and weaker at the level above the LSTV, resulting in destabilisation. The pseudoarticulated type 2 LSTVs have increased tracer uptake, while the fused type 3 LSTVs do not, and may be transmitting the forces superiorly or to the contralateral facet joint.
Some of these changes may be akin to the adjacent-level disease seen post fusion, with hypermobility accelerating degenerative change at the facet joints and disc. This analogy could also explain the increased rate of contralateral facet joint arthrosis in unilateral type 2 and type 3 LSTVs, with forces being transmitted to the contralateral side.
Assessing for nerve root symptoms in the presence of an LSTV lends to a few considerations, and may complicate assessment. Extraforaminal stenosis can occur with a nerve root being compressed between the hyperplastic transverse process of the LSTV and the adjacent sacral ala. Another explanation for nerve root symptoms is that disc prolapse can occur at the level above the LSTV at a greater rate than for those without an LSTV. Furthermore, in the absence of spondylolisthesis, spinal stenosis is also more likely to occur at the level above the LSTV.
Examination is complicated by the fact that there is variation in lower limb myotomes in those with an LSTV. With a sacralised L5, the L4 nerve root may function as the L5 nerve root. With a lumbarised S1, the S1 nerve root may function as the L5 nerve root. The functional L5 nerve root always originates at the lowest mobile lumbosacral level. Of note, normal lumbar plexuses have more individual differences than seen in the brachial plexus.
The IASP lists pseudoarthrosis of a transitional vertebra in their taxonomy, but not other potential causes of pain in the context of transitional anatomy. It isn't clear to the author if this is an intentional or unintentional omission. They only give one reference from 1989 so it is assumed to be an unintentional omission. The relevant pathology may be a periostitis that occurs due to repeated contact between the two bones with resultant sclerosis, but the majority are asymptomatic. They state that the diagnostic criteria are that the pseudoarthrosis must be present radiographically, and the pain must be relieved with selective aneasthetic injection of the pseudoarthrosis without having the anaesthetic spread to other structures that might suggest an alternative source of pain.
Effect on Nerve Roots
The findings some studies are limited by them typically not differentiating between those with "vertebral trade-off" (normal thoracolumbar vertebral count of 17) and those with a true excess or deficiency of vertebral enumeration (i.e. 16 or 18 thoracolumbar vertebra instead of 17).
A study of 111 cadavers found the following
- Thoracolumbar-trade off with 17 vertebrae: that in those with a thoracolumbar trade-off, differences were within the range of individual variation in normal lumbar plexuses.
- Thoracolumbar count of 16 vertebrae: There was a cranial shift of the upper limit of the lumbar plexus by 0.5-1 segments (iliohypogastric nerve), without a caudal shift, and the lumbosacral trunk remained the 24th spinal nerve.
- Thoracolumbar count of 18 vertebrae: with an increase of 2 segments from 16 to 18 there is a caudal shift of one segment of the nerve roots. The change may not be identifiable when comparing to normal spines.
When there is a true excess or deficiency in the number of vertebrae then the nerve roots are expected to shift up or down respectively. In those with a normal thoracolumbar count of 17 there are more individual differences than seen in the brachial plexus.
Treatment options include:
- Conservative management
- Contralateral facet joint: injections, radiofrequency neurotomy, surgical excision
- Ipsilateral transeverse process: surgical resection, injections of the pseudoarthrosis.
A systematic review by Holm et al in 2017 concluded that the evidence was low quality and no conclusions could be made. They found that steroid injections could improve symptoms but only temporarily, and surgical management could improve symptoms over time, but there were no head to head trials.
Thoracolumbar Transitional Anatomy
Throacolumbar transitional vertebrae (TLTV) may have hypoplastic ribs of <38mm in length, but this feature is not sufficient for detection.
|TV Location||Frequency||Vertebral Segments||Anatomical Features|
|T12||~2/3 of TLTV||24 (No additional)||Superior facets not directly posteriorly|
Intermediate mamillary bodies
No prominent transverse process
|L1||~1/3 of TLTV||Mostly 24
Rarely 25 with 6 lumbar vertebra
Rarely 25 with 13 thoracic vertebra and ribs
|No costal facets for ribs.|
Transverse process aplasia/hypoplasia
Superior facets asymmetrical and more posterior
Remnant mamillary bodies
Cervical Transitional Anatomy
Transitional anatomy can also occur at the atlanto-occipital junction (atlanto-occipital assimilation: complete or partial fusion of C1 and the occiput, occipital vertebra: an additional bone between C1 and the occiput), and at the cervicothoracic junction (cervical rib arising from C7).
- See Konin et al for an open access review on the lumbosacral transitional vertebral (LSTV) anatomy.
- See Furman et al for a practical approach, but unfortunately it is not open access.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ishiguro, Kaho; Kawashima, Tomokazu; Sato, Fumi (2020-12). "The phenotypic morphology of human lumbar plexus roots associated with changes in the thoracolumbar vertebral count and trade-off". Scientific Reports (in English). 10 (1): 127. doi:10.1038/s41598-019-56709-z. ISSN 2045-2322. PMC 6954195. PMID 31924812. Check date values in:
|date=(help)CS1 maint: PMC format (link)
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Konin & Walz. Lumbosacral transitional vertebrae: classification, imaging findings, and clinical relevance. AJNR. American journal of neuroradiology 2010. 31:1778-86. PMID: 20203111. DOI.
- ↑ 3.0 3.1 3.2 3.3 3.4 Carrino et al.. Effect of spinal segment variants on numbering vertebral levels at lumbar MR imaging. Radiology 2011. 259:196-202. PMID: 21436097. DOI.
- ↑ Uçar et al.. Retrospective cohort study of the prevalence of lumbosacral transitional vertebra in a wide and well-represented population. Arthritis 2013. 2013:461425. PMID: 23864947. DOI. Full Text.
- ↑ 5.0 5.1 Du Plessis et al.. Differentiation and classification of thoracolumbar transitional vertebrae. Journal of anatomy 2018. 232:850-856. PMID: 29363131. DOI. Full Text.
- ↑ Castellvi et al.. Lumbosacral transitional vertebrae and their relationship with lumbar extradural defects. Spine 1984. 9:493-5. PMID: 6495013. DOI.
- ↑ Pseudarthrosis of a Transitional Vertebra (XXVI-7). Classification of Chronic Pain, Second Edition (Revised). IASP. https://www.iasp-pain.org/PublicationsNews/Content.aspx?ItemNumber=1673
- ↑ Holm et al.. Symptomatic lumbosacral transitional vertebra: a review of the current literature and clinical outcomes following steroid injection or surgical intervention. SICOT-J 2017. 3:71. PMID: 29243586. DOI. Full Text.
- ↑ Furman et al.. Lumbosacral Transitional Segments: An Interventional Spine Specialist's Practical Approach. Physical medicine and rehabilitation clinics of North America 2018. 29:35-48. PMID: 29173663. DOI.
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