Rheumatology Symptoms Differential Diagnoses

From WikiMSK

Associated symptoms, signs, and conditions[1]
Category Symptom Possible diagnosis
Neurologic Headaches SLE, temporal arteritis
Numbness or paraesthesias Neuropathy - compression
Weakness Myositis, neuropathy
Stroke Antiphospholipid
Epilepsy SLE
Mouth Dry mouth Sjogren's Syndrome
Mouth ulcers Reactive arthritis, Behcet disease, IBD
Eyes Dry eyes Sjogren's Syndrome
Red eyes Spondyloarthritis
Visual loss Temporal arteritis
Skin Rash
Psoriasis Psoriatic arthritis
Livedo reticularis SLE
Erythema nodosum Acute sarcoid or erythema nodosum arthropathy
Respiratory Alopecia SLE
Pleuritis Connective tissue disease
Breathlessness Pulmonary involvement with inflammatory disease, e.g. systemic sclerosis, RA
Gastrointestinal Indigestion, history of peptic ulcer Nonsteroidal-associated gastritis or ulceration
Diarrhoeal illness Reactive arthritis, IBD
Genitourinary Renal stones Gout
Dysuria Reactive arthritis, Behçet disease, acute gonococcal arthritis
Genital ulcers Reactive arthritis, Behçet disease, acute gonococcal arthritis
Vaginal discharge Reactive arthritis, Behçet disease, acute gonococcal arthritis
Trauma Fracture Osteoporosis
Ligament rupture Osteoarthritis in the future
Sprains and strains Hypermobility syndrome
Nonspecific symptoms Malaise Inflammatory disease, malignancy
Fever SLE, septic arthritis
Weight loss Inflammatory disease, malignancy
Fatigue Inflammatory disease
Anorexia Inflammatory disease, malignancy
Aging Polymyalgia rheumatica
Haematologic Thrombosis or thromboembolism Antiphospholipid syndrome
Anaemia Inflammatory
Obstetric history Fetal loss—early and


Antiphospholipid syndrome
Intrauterine growth retardation Antiphospholipid syndrome
Preeclampsia Antiphospholipid syndrome
  1. Rheumatology - Hochberg 2019