Sacroiliac Joint Precision Treatment
A variety of radiofrequency procedures have been developed for the treatment of proven sacroiliac joint pain. The term "precision treatment" refers to treatment of a proven pain generator unlike treating "non-specific low back pain." In research either an intraarticular block or lateral branch blocks are performed for precision diagnosis, and two blocks are preferred to reduce the false positive rate. Lateral branch blocks do not necessarily block sensory information from the ventral surface of the joint. A 2015 systematic review by Simopopoulos et al of radiofrequency procedures found high heterogeneity, and a meta-analysis was not feasible. In general cooled radiofrequency is the only procedure with positive RCT evidence [Level 2]. The author is not aware of any Musculoskeletal Medicine specialists in New Zealand using cooled radiofrequency neurotomy for any use case. Traditional radiofrequency neurotomy for sacroiliac joint pain does not have good evidence. Repeated intraarticular prolotherapy injections is another treatment option with some evidence. [Level 2]
There are two RCTs based on controlled blocks. An anteroposterior approach is faster and equal in efficacy to the traditional oblique approach.
|Kim 2010 (RCT)||50||
||1 x positive intraarticular block (>50% pain relief)||✅Positive study
|Jee 2014 (RCT)||120||
||1 x positive intraarticular block (>80% pain relief)||Focused more on accuracy of ultrasound rather than outcomes
Ultrasound group: 87% accuracy, Fluoroscopic group: 98.2% accuracy No difference in pain scores and ODI at 2 and 12 weeks.
|Looking at the utility of using ultrasound versus fluoroscopy|
One retrospective case series investigated 150 patients with sacroiliac joint pain diagnosed clinically. All first had intraarticular bupivacaine and triamcinolone. 88 had at least 75% pain relief. Of those 88, 58 had a second injection of which 39 had further relief. Of those final 39 patients, 13 had at least 50% relief that lasted less than 6 weeks, and 26 (45%) had relief that lasted longer than 6 weeks (36.8 ± 9.9 weeks)
No RCTs used controlled blocks for diagnosis. 2 x non-precision RCTs (Luukkainen et al 1999 and 2002) both positive results for steroid over saline.
Sacroiliac Joint Innervation
This topic is controversial. The literature is confusing because some studies have selected by positive lateral branch blocks, while others have selected by intraarticular blocks. Theoretically patients should be selected by lateral branch blocks.
- Ventral surface: Ventral root of L4/L5 – S2, or branches from sacral plexus
- Dorsal surface: Dorsal root of L4/L5, and S1-3 lateral branches.
- Ligaments: S1-3 lateral branches
Location is variable person to person, side to side, and level to level.
Cooled Radiofrequency Neurotomy
Cooled radiofrequency neurotomy techniques are the only intervention with positive RCT evidence.
|Cohen et al 2008 (RCT)||28||
1. Cooled radiofrequency ablation of S1 to S3 lateral branches, and L5 dorsal ramus
|Single intraarticular block (>75% pain relief)||✅Positive study
Success defined as pain <50%
|Patel et al 2012 + 2015 (RCT)||120||
1. Cooled radiofrequency ablation of S1 to S3 lateral branches, and L5 dorsal ramus
|Two positive blocks lateral branches (>75% pain relief)||✅Positive study
Success defined as pain <50% plus improvement in another measure
A retrospective trial by Cheng et al in 2013 compared cooled RF and traditional RF. Patients were selected based on >50% pain relief to two positive IA blocks. The two groups had equal outcomes. Success was defined as >50% pain relief. At 3 months: 50-60% both groups, 6 months: 40% both groups, 9 months: 30% both groups. There was bias potentially favouring CRF overall. The CRF group was younger, had more steroid (there was optional steroid given at the time to reduce neuritis), more lesions per level, and the patients had more previous spine surgery.
A meta-analysis was published in 2018 that included 7 studies, with 2 RCTs. Cooled RF had a mean 3.81 NRS reduction. Both RCTs were assessed as low risk of bias.
Other Radiofrequency Techniques
There is no positive RCT evidence for other techniques such as conventional, pulsed, strip, or bipolar radiofrequency neurotomy. Cohen in 2009 published a study which found that the only predictor of success was whether cooled RF was used. 
There is one negative RCT looking at the Simplicity III probe which allows a single point of entry to ablate the sacroiliac joint innervation in a strip lesion, plus a secondary entry point for the L5 dorsal root.
A non placebo controlled trial used heterogenous techniques (cooled, bipolar or simplicity III) and had negative results. This study, one part of a set of three RCTs on spinal RF treatments, has received a large amount of critisism.
There are two positive non-placebo controlled RCTs evaluating minimally invasive sacroiliac joint fusion with the iFUSE implant system for confirmed sacroiliac joint pain based on a positive diagnostic block with greater than 50% pain relief.  There were large improvements in pain and disability over the control group of conventional medical management. Polly et al allowed radiofrequency procedures, while Dengler et al didn't. These studies were industry funded, partially industry authored and had no sham group and so should be interpreted with caution.
The iFUSE system involves the fluoroscopic insertion of 2-4 triangular implants through the ilium across the sacroiliac joint into the centre of the sacrum lateral to the neural foramina. The implant is coated with a porous material allowing fixation of bone. The triangular shape allows immediate stabilisation and minimises micromotion and rotation of the joint.
- Intraarticular prolotherapy injections: [Level 2]
- Intraarticular steroid injections: [Level 4]
- Periarticular injections: [Level 4]
- RF neurotomy: ~40% have >50% pain relief at 6 months, cooled and traditional may be equal.[Level 3]
- Minimally invasive fusion: [Level 2]
- Lumbar Disc Precision Treatment
- Lumbar Facet Joint Precision Treatment
- Radiofrequency Neurotomy
- Chronic Low Back Pain
- Causes and Sources of Chronic Low Back Pain
- Simopoulos et al.. Systematic Review of the Diagnostic Accuracy and Therapeutic Effectiveness of Sacroiliac Joint Interventions. Pain physician 2015. 18:E713-56. PMID: 26431129.
- Chauhan et al.. A Randomized Controlled Trial of Fluoroscopically-Guided Sacroiliac Joint Injections: A Comparison of the Posteroanterior and Classical Oblique Techniques. Neurospine 2019. 16:317-324. PMID: 30531656. DOI. Full Text.
- Kim et al.. A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain. Journal of alternative and complementary medicine (New York, N.Y.) 2010. 16:1285-90. PMID: 21138388. DOI.
- Jee H, Lee JH, Park KD, Ahn J, Park Y. Ultrasound-guided versus fluoroscopy-guided sacroiliac joint intra-articular injections in the noninflammatory sacroiliac joint dysfunction: a prospective, randomized, single-blinded study. Arch Phys Med Rehabil. 2014;95(2):330-337. doi:10.1016/j.apmr.2013.09.021
- Liliang PC, Lu K, Weng HC, Liang CL, Tsai YD, Chen HJ. The therapeutic efficacy of sacroiliac joint blocks with triamcinolone acetonide in the treatment of sacroiliac joint dysfunction without spondyloarthropathy. Spine (Phila Pa 1976). 2009 Apr 20;34(9):896-900. doi: 10.1097/BRS.0b013e31819e2c78. PMID: 19531998.
- King and Bogduk. Chronic Low Back Pain In: Bonica's Management of Pain. 2018
- Cohen et al.. Randomized placebo-controlled study evaluating lateral branch radiofrequency denervation for sacroiliac joint pain. Anesthesiology 2008. 109:279-88. PMID: 18648237. DOI. Full Text.
- Patel. Twelve-Month Follow-Up of a Randomized Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Region Pain. Pain practice : the official journal of World Institute of Pain 2016. 16:154-67. PMID: 25565322. DOI.
- Cheng et al.. Comparative outcomes of cooled versus traditional radiofrequency ablation of the lateral branches for sacroiliac joint pain. The Clinical journal of pain 2013. 29:132-7. PMID: 22688606. DOI.
- Sun et al.. The efficacy and safety of using cooled radiofrequency in treating chronic sacroiliac joint pain: A PRISMA-compliant meta-analysis. Medicine 2018. 97:e9809. PMID: 29419679. DOI. Full Text.
- Cohen et al.. Outcome predictors for sacroiliac joint (lateral branch) radiofrequency denervation. Regional anesthesia and pain medicine 2009. 34:206-14. PMID: 19587617. DOI.
- van Tilburg et al.. Randomized Sham-controlled Double-Blind Multicenter Clinical Trial to Ascertain the Effect of Percutaneous Radiofrequency Treatment for Sacroiliac Joint Pain: Three-month Results. The Clinical journal of pain 2016. 32:921-926. PMID: 26889616. DOI. Full Text.
- Juch et al.. Effect of Radiofrequency Denervation on Pain Intensity Among Patients With Chronic Low Back Pain: The Mint Randomized Clinical Trials. JAMA 2017. 318:68-81. PMID: 28672319. DOI. Full Text.
- Polly et al.. Two-Year Outcomes from a Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion vs. Non-Surgical Management for Sacroiliac Joint Dysfunction. International journal of spine surgery 2016. 10:28. PMID: 27652199. DOI. Full Text.
- Dengler et al.. Randomized Trial of Sacroiliac Joint Arthrodesis Compared with Conservative Management for Chronic Low Back Pain Attributed to the Sacroiliac Joint. The Journal of bone and joint surgery. American volume 2019. 101:400-411. PMID: 30845034. DOI. Full Text.
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