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It is particularly relevant in neuropathic pain, alloknesis, and the use of antihistamines in neuropathic pain. Histamine, or 2-(4-imidazolyl)-ethylamine

Low back pain is not loin pain, nor is it gluteal pain. The IASP taxonomy categorises low back pain into lumbar spinal pain and sacral spinal pain. There

potentials (See also Basic Neurophysiology and Channelopathies and Chronic Pain). Disease associated mutations have been identified for all major voltage-gated

categorised into: Exteroceptors: present in skin and provide nociception (pain, temperature, touch, pressure) Interorecptors: present in viscera and provide

inflammatory and neuropathic pain. Some of the other ion channel changes seen in chronic pain include:channelopathies linked to chronic pain include: TRPV1-related

information regarding pain, temperature, and crude touch. Small-diameter unmyelinated axons from the dorsal root ganglion that carry pain, temperature, and

Rowbotham MC. Placebo response in neuropathic pain trials. Pain. 2008 Sep 15;138(3):479-483. doi: 10.1016/j.pain.2008.06.024. Epub 2008 Aug 15. PMID: 18706762

coping strategy for chronic pain is associated with greater pain intensity and poorer pain-related function". The Journal of Pain. 13 (3): 285–292. doi:10

neck pain. Pain physician 2002. 5:243-9. PMID: 16902649. Yin & Bogduk. The nature of neck pain in a private pain clinic in the United States. Pain medicine

anterior knee pain is the most common symptoms. In those where pain is triggered by walking up and down stairs one should consider patellofemoral pain syndrome

information itself does not constitute pain, and is not pain until that information reaches the brain. Stimuli that elicits pain is commonly termed noxious. The

chronic pain than European/other. Around one fifth of people with chronic pain have predominantly neuropathic pain.[citation needed] Neuropathic pain is more

to help explain how stresses at one point in the body can lead to referred pain and help inform functional approaches to treating musculoskeletal disorders

Neurophysiology Hans-Georg Schaible. Articular Nociceptors. Encyclopedia of Pain 2013.

Nociception Neuropathic Pain Robert LaMotte. Allodynia and Alloknesis. Encyclopedia of Pain 2013 John Scadding. Hyperpathia. Encyclopedia of Pain 2013. Atanassoff

Flags Sudden onset of acute pain Trauma Pain not improved by rest Pain so severe that weight bearing isn't possible The pain is often poorly localised.

that are typically self-limiting. They are typically part of normal human physiology but can be associated with a wide range of acquired and inherited causes

Bradykinin both activates and sensitises sensory neurons. it is a very potent pain-producing substance. Following the release with injury or inflammation, it